Multidimensional processing in the amygdala.

Multidimensional processing in the amygdala.
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DOI:
10.1038/s41583-020-0350-y
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发表时间:
2020-10
期刊:
Nature reviews. Neuroscience
影响因子:
--
通讯作者:
Gothard KM
Gothard KM
中科院分区:
其他
文献类型:
--
作者:
Gothard KM

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协调情感和社会行为的全脑回路在杏仁核中交叉。因此,杏仁核病变会导致一系列社会和非社会缺陷。尽管携带社会信号的输入和输出在解剖学上被限制在不同的亚核区域,但社会行为并不局限于杏仁核的分区。这一观察结果可以解释的组成神经元的多维响应特性。事实上,杏仁核中汇聚的众多回路将相同的神经元子集集合成不同的集合体,这些集合体将社会和非社会元素联合收割机组合成高维表征。这些表示可以实现灵活的、上下文相关的社交决策。因此,多维处理可以与遗传上相同的神经元的子回路并行操作,这些神经元提供专门的和功能上可分离的功能。当结合在一起时,专门回路的活动可能会赋予社会行为特异性,而多维处理则有助于复杂社会行为所需的灵活性和细微差别。
Brain-wide circuits that coordinate affective and social behaviours intersect in the amygdala. Consequently, amygdala lesions cause a heterogeneous array of social and non-social deficits. Social behaviours are not localized to subdivisions of the amygdala even though the inputs and outputs that carry social signals are anatomically restricted to distinct subnuclear regions. This observation may be explained by the multidimensional response properties of the component neurons. Indeed, the multitudes of circuits that converge in the amygdala enlist the same subset of neurons into different ensembles that combine social and non-social elements into high-dimensional representations. These representations may enable flexible, context-dependent social decisions. As such, multidimensional processing may operate in parallel with subcircuits of genetically identical neurons that serve specialized and functionally dissociable functions. When combined, the activity of specialized circuits may grant specificity to social behaviours, whereas multidimensional processing facilitates the flexibility and nuance needed for complex social behaviour.
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