Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain.

Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain.
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粪便微生物移植:从肠道到大脑的新治疗尝试

DOI:
10.1155/2021/6699268
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发表时间:
2021
影响因子:
2
通讯作者:
Nie YQ
Nie YQ
中科院分区:
医学4区
文献类型:
--
作者:
Xu HM;Huang HL;Zhou YL;Zhao HL;Xu J;Shou DW;Liu YD;Zhou YJ;Nie YQ

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肠道菌群失调与各种肠道及肠外疾病密切相关。粪便微生物群移植(FMT)是一种生物疗法,其需要将肠道微生物群从健康个体转移到患者以重建后者的肠道微生物群。它已被证明是一种有效的治疗复发性艰难梭菌感染。研究表明,肠道微生物群通过微生物群-肠道-脑轴在神经和精神疾病的病理生理学中起着重要作用。因此,重建健康的肠道微生物群是治疗脑疾病的一种有前途的新策略。我们回顾了肠道微生物群在不同神经系统疾病中的作用以及FMT在神经系统、精神系统和其他神经系统相关疾病(帕金森病、阿尔茨海默病、多发性硬化症、癫痫、自闭症谱系障碍、双相情感障碍、肝性脑病、神经性疼痛等)中的应用背景下的最新研究。
Gut dysbacteriosis is closely related to various intestinal and extraintestinal diseases. Fecal microbiota transplantation (FMT) is a biological therapy that entails transferring the gut microbiota from healthy individuals to patients in order to reconstruct the intestinal microflora in the latter. It has been proved to be an effective treatment for recurrent Clostridium difficile infection. Studies show that the gut microbiota plays an important role in the pathophysiology of neurological and psychiatric disorders through the microbiota-gut-brain axis. Therefore, reconstruction of the healthy gut microbiota is a promising new strategy for treating cerebral diseases. We have reviewed the latest research on the role of gut microbiota in different nervous system diseases as well as FMT in the context of its application in neurological, psychiatric, and other nervous system-related diseases (Parkinson's disease, Alzheimer's disease, multiple sclerosis, epilepsy, autism spectrum disorder, bipolar disorder, hepatic encephalopathy, neuropathic pain, etc.).
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