DNA damage, chromatin, and transcription: the trinity of aging.
DNA damage, chromatin, and transcription: the trinity of aging.
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DOI:
10.1016/j.ceb.2012.07.005
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发表时间:
2012-12
影响因子:
7.5
通讯作者:
Oberdoerffer, Philipp
中科院分区:
文献类型:
--
作者:
Burgess, Rebecca C.;Misteli, Tom;Oberdoerffer, Philipp
Aging brings about numerous cellular defects. Amongst the most prominent are elevated levels of persistent DNA damage, changes to chromatin structure and epigenetic modifications, and alterations of global transcription programs. These are not independent events and recent work begins to shed light on the intricate interplay between these aging-related defects.
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