Activins and inhibins: novel regulators of thymocyte development.
Activins and inhibins: novel regulators of thymocyte development.
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DOI：
10.1016/j.bbrc.2009.02.029
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发表时间：
2009-04-03
影响因子：
3.1
通讯作者：
Soldevila, Gloria
中科院分区：
文献类型：
--
作者：
Licona-Limon, Paula;Aleman-Muench, German;Chimal-Monroy, Jesus;Macias-Silvac, Marina;Garcia-Zepeda, Eduardo A.;Matzuk, Martin M.;Fortoul, Teresa I.;Soldevila, Gloria
激活素和β-胡萝卜素是转化生长因子β超家族的成员，它们作用于不同的细胞类型并调节广泛的细胞过程，包括增殖、分化和凋亡。在这里，我们提供的第一个证据表明，激活素和tubin调节胸腺细胞发育过程中的特定检查点。我们证明，激活素A和白蛋白A促进体外DN 3-DN 4转换，虽然他们差异控制DP阶段的过渡。尽管激活素A诱导⑶ 8 + ⑶ 24 hiTCR β 1 〇中间亚群的积累，但白蛋白A促进DN 4向DP的分化。此外，激活素A和抑制素A似乎都促进CD 8 +SP分化。此外，抑制素α缺失小鼠延迟了体外T细胞发育，显示DN-DP转换减少和胸腺细胞数量减少，进一步支持了抑制素A在体内T细胞分化期间控制发育信号的作用。
Activins and inhibins are members of the transforming growth factor β superfamily that act on different cell types and regulate a broad range of cellular processes including proliferation, differentiation, and apoptosis. Here, we provide the first evidence that activins and inhibins regulate specific checkpoints during thymocyte development. We demonstrate that both activin A and inhibin A promote the DN3-DN4 transition in vitro, although they differentially control the transition to the DP stage. Whereas activin A induces the accumulation of a CD8+CD24hiTCRβlo intermediate subpopulation, inhibin A promotes the differentiation of DN4 to DP. In addition, both activin A and inhibin A appear to promote CD8+SP differentiation Moreover, Inhibin α null mice have delayed in vitro T cell development, showing both a decrease in the DN-DP transition and reduced thymocyte numbers, further supporting a role for inhibins in the control of developmental signals taking place during T cell differentiation in vivo.
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影响因子：
64.8
作者：
MATZUK, MM;FINEGOLD, MJ;BRADLEY, A
通讯作者：
BRADLEY, A
影响因子：
15.3
作者：
Graf, D;Nethisinghe, S;Merkenschlager, M
通讯作者：
Merkenschlager, M
影响因子：
2.5
作者：
Licona, P;Chimal-Monroy, J;Soldevila, G
通讯作者：
Soldevila, G
DOI：
10.1016/0167-5699(95)80179-0
发表时间：
1995-06-01
期刊：
IMMUNOLOGY TODAY
影响因子：
--
作者：
SCOLLAY, R;GODFREY, DI
通讯作者：
GODFREY, DI
影响因子：
5.4
作者：
Gabor, MJ;Godfrey, DI;Scollay, R
通讯作者：
Scollay, R