A preliminary study of functional abnormalities in aMCI subjects during different episodic memory tasks.
A preliminary study of functional abnormalities in aMCI subjects during different episodic memory tasks.
复制标题
DOI：
10.1016/j.mri.2011.12.014
复制
发表时间：
2012-05
影响因子：
2.5
通讯作者：
Cordes, Dietmar
中科院分区：
文献类型：
--
作者：
Jin, Mingwu;Pelak, Victoria S.;Curran, Tim;Nandy, Rajesh R.;Cordes, Dietmar
关键词：
功能磁共振成像（fMRI）是了解轻度认知功能障碍（MCI）和早期阿尔茨海默病（AD）神经退行性变过程的重要影像学手段，因为记忆功能障碍可能发生在结构退化明显之前。在这项研究中，我们调查了遗忘型MCI（aMCI）的主体功能异常使用三个情景记忆范式，这是相关的不同的记忆域在编码和识别阶段。采用全脑分析和内侧颞叶（MTL）的感兴趣区（ROI）分析方法，比较aMCI患者和正常对照者不同记忆范式的效率和功能差异。我们还研究了在ROI分析中使用不同功能激活测量的影响。这项初步研究可以促进MTL功能磁共振成像激活作为早期检测和监测AD进展的标志物的使用。
Functional MRI (fMRI) is an important imaging modality to understand the neurodegenerative course of mild cognitive impairment (MCI) and early Alzheimer's disease (AD) because the memory dysfunction may occur before structural degeneration is obvious. In this research, we investigated the functional abnormalities of subjects with amnestic MCI (aMCI) using three episodic memory paradigms that are relevant to different memory domains in both encoding and recognition phases. Both whole brain analysis and region-of-interest (ROI) analysis on the medial temporal lobes (MTL), which are central to the memory formation and retrieval, were used to compare the efficiency of the different memory paradigms and the functional difference between aMCI subjects and normal control subjects. We also investigated the impact of using different functional activation measurements in ROI analysis. This pilot study could facilitate the use of fMRI activations in MTL as a marker for early detection and monitoring progression of AD.
登录
查看更多内容
影响因子：
14
作者：
Brookmeyer, Ron;Johnson, Elizabeth;Arrighi, H. Michael
通讯作者：
Arrighi, H. Michael
影响因子：
2.5
作者：
Andrews-Hanna, Jessica R.;Reidler, Jay S.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
14.5
作者：
Golby, AJ;Poldrack, RA;Gabrieli, JDE
通讯作者：
Gabrieli, JDE
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
9.9
作者：
Dickerson, BC;Salat, DH;Sperling, RA
通讯作者：
Sperling, RA