Sleep disturbance as a transdiagnostic marker of psychiatric risk in children with neurodevelopmental risk genetic conditions.
Sleep disturbance as a transdiagnostic marker of psychiatric risk in children with neurodevelopmental risk genetic conditions.
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DOI：
10.1038/s41398-022-02296-z
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发表时间：
2023-01-11
影响因子：
6.8
通讯作者：
van den Bree, Marianne B. M.
中科院分区：
文献类型：
--
作者：
Chawner, Samuel J. R. A.;Evans, Alexandra;Williams, Nigel J.;Owen, Michael;Hall, Jeremy;van den Bree, Marianne B. M.
患有罕见神经发育遗传疾病(ND-GC)的儿童患一系列神经精神疾病的风险很高。睡眠症状学可能代表着这一患者组中的跨诊断风险指标。在这里，我们展示了629名患有ND-GCs的儿童的数据，这些儿童是通过英国国家卫生服务医疗遗传学诊所招募的。兄弟姐妹对照(183人)也被邀请参加。与对照组相比，详细的评估被用来描述ND-GCs儿童的睡眠表型。根据睡眠症状对ND-GC患儿进行潜伏期分析。通过对认知和精神病理学的评估，可以调查睡眠表型亚组是否与神经精神病学结果相关。我们发现，与对照组相比，患有ND-GC的儿童失眠的风险更高(ND-GC = 41%比对照组 = 17%，p <； 0.001)，并至少经历一种睡眠症状(ND-GC = 66%比对照组 = 39%，p <； 0.001)。平均而言，失眠被发现在患有ND-GC的儿童中起病较早(2.8岁)，并影响多种背景。与高睡眠症状相关的亚组中的儿童也有很高的精神后果风险(OR从2.0到21.5不等，取决于精神状况)。我们的发现表明，神经发育结果具有高遗传易感性的儿童表现出高失眠率和睡眠症状。睡眠障碍对心理社会功能有广泛的影响，并表明这些儿童具有更大的神经精神风险。失眠被发现发生在儿童早期，强调了通过睡眠状况了解精神疾病风险的早期干预策略的可能性。
Children with rare neurodevelopmental genetic conditions (ND-GCs) are at high risk for a range of neuropsychiatric conditions. Sleep symptomatology may represent a transdiagnostic risk indicator within this patient group. Here we present data from 629 children with ND-GCs, recruited via the United Kingdom’s National Health Service medical genetic clinics. Sibling controls (183) were also invited to take part. Detailed assessments were conducted to characterise the sleep phenotype of children with ND-GCs in comparison to controls. Latent class analysis was conducted to derive subgroups of children with an ND-GC based on sleep symptomatology. Assessment of cognition and psychopathology allowed investigation of whether the sleep phenotypic subgroup was associated with neuropsychiatric outcomes. We found that children with an ND-GC, when compared to control siblings, were at elevated risk of insomnia (ND-GC = 41% vs Controls = 17%, p < 0.001) and of experiencing at least one sleep symptom (ND-GC = 66% vs Controls = 39%, p < 0.001). On average, insomnia was found to have an early onset (2.8 years) in children with an ND-GC and to impact across multiple contexts. Children in subgroups linked to high sleep symptomatology were also at high risk of psychiatric outcomes (OR ranging from 2.0 to 21.5 depending on psychiatric condition). Our findings demonstrate that children with high genetic vulnerability for neurodevelopmental outcomes exhibit high rates of insomnia and sleep symptomatology. Sleep disruption has wide-ranging impacts on psychosocial function, and indexes those children at greater neuropsychiatric risk. Insomnia was found to onset in early childhood, highlighting the potential for early intervention strategies for psychiatric risk informed by sleep profile.
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神经精神风险拷贝数变异的患者的临床评估。
影响因子：
4
作者：
Chawner SJ;Watson CJ;Owen MJ
通讯作者：
Owen MJ
DOI：
10.1176/appi.ajp.2020.20010015
发表时间：
2021-01-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Chawner SJRA;Doherty JL;Anney RJL;Antshel KM;Bearden CE;Bernier R;Chung WK;Clements CC;Curran SR;Cuturilo G;Fiksinski AM;Gallagher L;Goin-Kochel RP;Gur RE;Hanson E;Jacquemont S;Kates WR;Kushan L;Maillard AM;McDonald-McGinn DM;Mihaljevic M;Miller JS;Moss H;Pejovic-Milovancevic M;Schultz RT;Green-Snyder L;Vorstman JA;Wenger TL;IMAGINE-ID Consortium;Hall J;Owen MJ;van den Bree MBM
通讯作者：
van den Bree MBM
影响因子：
9.3
作者：
Dauvilliers Y;Lopez R;Ohayon M;Bayard S
通讯作者：
Bayard S
影响因子：
2.6
作者：
Halstead EJ;Joyce A;Sullivan E;Tywyn C;Davies K;Jones A;Dimitriou D
通讯作者：
Dimitriou D
影响因子：
7.6
作者：
Jeppesen, Pia;Clemmensen, Lars;Skovgaard, Anne M.
通讯作者：
Skovgaard, Anne M.