Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury.
Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury.
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DOI：
10.1038/nn.2691
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发表时间：
2010-12
影响因子：
25
通讯作者：
Tuszynski, Mark H.
中科院分区：
文献类型：
--
作者：
Rosenzweig, Ephron S.;Courtine, Gregoire;Jindrich, Devin L.;Brock, John H.;Ferguson, Adam R.;Strand, Sarah C.;Nout, Yvette S.;Roy, Roland R.;Miller, Darren M.;Beattie, Michael S.;Havton, Leif A.;Bresnahan, Jacqueline C.;Edgerton, V. Reggie;Tuszynski, Mark H.
虽然中枢神经系统损伤后的轴突再生是有限的，但部分损伤往往伴随着广泛的功能恢复。为了研究脊髓不完全损伤后自发恢复的机制，成年恒河猴接受C7脊髓半切，随后分析行为，电生理和解剖适应。我们发现了显着的自发可塑性的皮质脊髓的预测，重建完全60%的损伤前轴突密度所产生的脊髓中线交叉轴突发芽。这种广泛的解剖学恢复与协调肌肉募集、手功能和运动的改善有关。这些发现确定了迄今为止观察到的神经系统损伤后哺乳动物轴突投射的最广泛的自然恢复，突出了灵长类动物模型在转化疾病研究中的重要作用。
While axonal regeneration after CNS injury is limited, partial injury is frequently accompanied by extensive functional recovery. To investigate mechanisms underlying spontaneous recovery after incomplete spinal cord injury, adult rhesus monkeys underwent C7 spinal cord hemisections, with subsequent analysis of behavioral, electrophysiological and anatomical adaptations. We found remarkable spontaneous plasticity of corticospinal projections, with reconstitution of fully 60% of pre-lesion axon density arising from sprouting of spinal cord midline-crossing axons. This extensive anatomical recovery was associated with improvement in coordinated muscle recruitment, hand function and locomotion. These findings identify what may be the most extensive natural recovery of mammalian axonal projections after nervous system injury observed to date, highlighting an important role for primate models in translational disease research.
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影响因子：
2.5
作者：
Lacroix, S;Havton, LA;Tuszynski, MH
通讯作者：
Tuszynski, MH
影响因子：
64.8
作者：
HAVTON, L;KELLERTH, JO
通讯作者：
KELLERTH, JO
影响因子：
5.3
作者：
Brus-Ramer, Marcel;Carmel, Jason B.;Martin, John H.
通讯作者：
Martin, John H.
影响因子：
7
作者：
MacCallum, RC;Widaman, KF;Hong, SH
通讯作者：
Hong, SH
DOI：
10.1523/jneurosci.1924-10.2010
发表时间：
2010-07-21
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Brock JH;Rosenzweig ES;Blesch A;Moseanko R;Havton LA;Edgerton VR;Tuszynski MH
通讯作者：
Tuszynski MH