Human versus mouse eosinophils: "that which we call an eosinophil, by any other name would stain as red".
Human versus mouse eosinophils: "that which we call an eosinophil, by any other name would stain as red".
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DOI：
10.1016/j.jaci.2012.07.025
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发表时间：
2012-09
影响因子：
14.2
通讯作者：
Lee, Nancy A.
中科院分区：
文献类型：
--
作者：
Lee, James J.;Jacobsen, Elizabeth A.;Ochkur, Sergei I.;McGarry, Michael P.;Condjella, Rachel M.;Doyle, Alfred D.;Luo, Huijun;Zellner, Katie R.;Protheroe, Cheryl A.;Willetts, Lian;LeSuer, William E.;Colbert, Dana C.;Helmers, Richard A.;Lacy, Paige;Moqbel, Redwan;Lee, Nancy A.
人类和小鼠各自的生活史被很好地定义，并描述了一个独特的进化保守故事，从基因组中的序列同一性延伸到生化、细胞和生理途径的基础。因此，这两个物种的造血血统都得到了始终如一的维持，每个物种都有可识别的嗜酸性粒细胞。然而，这种规范的存在并不排除人和小鼠的嗜酸性粒细胞和/或它们的效应器功能之间的差异。事实上，许多书籍和评论都教条式地强调差异，为使用人类嗜酸性粒细胞疾病的小鼠模型提供了理由。我们认为这种观点是狭隘的，忽视了现有研究的丰富和文献的共识，即人和老鼠的嗜酸性粒细胞之间存在着压倒性的相似(而不是不同)。这篇综述的目的是总结这些文献，并在某些情况下提供实验细节，比较和对比人类和小鼠的嗜酸性粒细胞和嗜酸性粒细胞效应器的功能。特别是，我们的综述将为重要研究提供一个总结和一个易于使用的参考指南，这些研究表明，尽管存在差异，但它们的后果往往是未知的，并不一定反映嗜酸性粒细胞功能的内在差异，而是物种特有的变异。这一综述的结论是，尽管存在名义上的差异，但人类和小鼠嗜酸性粒细胞之间的巨大相似之处为它们在健康和疾病中的作用提供了重要的见解，并反过来展示了基于小鼠的研究的独特效用，期望有效的外推来理解和治疗患者。
The respective life histories of humans and mice are well defined and describe a unique story of evolutionary conservation extending from sequence identity within the genome to the underpinnings of biochemical, cellular, and physiological pathways. As a consequence, the hematopoietic lineages of both species are invariantly maintained, each with identifiable eosinophils. This canonical presence nonetheless does not preclude disparities between human and mouse eosinophils and/or their effector functions. Indeed, many books and reviews dogmatically highlight differences, providing a rationale to discount the use of mouse models of human eosinophilic diseases. We suggest that this perspective is parochial and ignores the wealth of available studies and the consensus of the literature that overwhelming similarities (and not differences) exist between human and mouse eosinophils. The goal of this review is to summarize this literature and in some cases provide the experimental details, comparing and contrasting eosinophils and eosinophil effector functions in humans vs. mice. In particular, our review will provide a summation and an easy to use reference guide to important studies demonstrating that while differences exist, more often than not their consequences are unknown and do not necessarily reflect inherent disparities in eosinophil function, but instead, species-specific variations. The conclusion from this overview is that despite nominal differences, the vast similarities between human and mouse eosinophils provide important insights as to their roles in health and disease and, in turn, demonstrate the unique utility of mouse-based studies with an expectation of valid extrapolation to the understanding and treatment of patients.
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DOI：
10.1097/aci.0b013e328334f693
发表时间：
2010-02
影响因子：
2.8
作者：
Akuthota P;Wang H;Weller PF
通讯作者：
Weller PF
影响因子：
9.8
作者：
Church DM;Goodstadt L;Hillier LW;Zody MC;Goldstein S;She X;Bult CJ;Agarwala R;Cherry JL;DiCuccio M;Hlavina W;Kapustin Y;Meric P;Maglott D;Birtle Z;Marques AC;Graves T;Zhou S;Teague B;Potamousis K;Churas C;Place M;Herschleb J;Runnheim R;Forrest D;Amos-Landgraf J;Schwartz DC;Cheng Z;Lindblad-Toh K;Eichler EE;Ponting CP;Mouse Genome Sequencing Consortium
通讯作者：
Mouse Genome Sequencing Consortium
DOI：
10.4049/jimmunol.0904043
发表时间：
2010-06-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Dyer KD;Percopo CM;Xie Z;Yang Z;Kim JD;Davoine F;Lacy P;Druey KM;Moqbel R;Rosenberg HF
通讯作者：
Rosenberg HF
影响因子：
7.2
作者：
Bloom, JW;Chacko, J;Miesfeld, RL
通讯作者：
Miesfeld, RL
DOI：
10.1016/s0960-0760(03)00065-7
发表时间：
2003-03-01
影响因子：
4.1
作者：
Chauhan, S;Leach, CH;Miesfeld, RL
通讯作者：
Miesfeld, RL