Attention-related changes in correlated neuronal activity arise from normalization mechanisms.
Attention-related changes in correlated neuronal activity arise from normalization mechanisms.
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DOI：
10.1038/nn.4572
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发表时间：
2017-07
影响因子：
25
通讯作者：
Maunsell JHR
中科院分区：
文献类型：
--
作者：
Verhoef BE;Maunsell JHR
注意力被认为通过改变神经元对之间的相关性来增强感知。注意力如何改变神经元的相关性尚不清楚。使用多电极在灵长类动物的视觉皮层，我们测量了尖峰计数的相关性时，单一或多个刺激，刺激出席或不出席。当刺激是无人看管的，添加一个抑制性的，非首选的，刺激旁边的首选刺激增加尖峰计数之间的相关性对相似的调谐神经元，但减少尖峰计数之间的相关性对相反调谐神经元。这些变化是由一个随机的正常化模型，包含人口的相反调整，相互抑制的神经元。重要的是，这个模型还解释了为什么注意力减少（注意偏好刺激）或增加（注意非偏好刺激）的相关性：这是正常化机制输入中与注意力相关的变化的间接结果。我们的研究结果链接正常化机制相关的神经元活动和注意力，表明正常化机制的形状响应的相关性，这些相关性的变化时，注意力偏差的正常化机制。
Attention is believed to enhance perception by altering the correlations between pairs of neurons. How attention changes neuronal correlations is unknown. Using multi-electrodes in primate visual cortex, we measured spike-count correlations when single or multiple stimuli were presented, and stimuli were attended or unattended. When stimuli were unattended, adding a suppressive, non-preferred, stimulus beside a preferred stimulus increased spike-count correlations between pairs of similarly-tuned neurons, but decreased spike-count correlations between pairs of oppositely-tuned neurons. These changes are explained by a stochastic normalization model containing populations of oppositely-tuned, mutually-suppressive neurons. Importantly, this model also explains why attention decreased (attend preferred stimulus) or increased (attend non-preferred stimulus) correlations: as an indirect consequence of attention-related changes in the inputs to normalization mechanisms. Our findings link normalization mechanisms to correlated neuronal activity and attention, showing that normalization mechanisms shape response correlations and that these correlations change when attention biases normalization mechanisms.
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