I'm so tired: biological and genetic mechanisms of cancer-related fatigue.
I'm so tired: biological and genetic mechanisms of cancer-related fatigue.
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DOI：
10.1007/s11136-010-9757-7
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发表时间：
2010-12
影响因子：
3.5
通讯作者：
Halyard, Michele
中科院分区：
文献类型：
--
作者：
Barsevick, Andrea;Frost, Marlene;Zwinderman, Aeilko;Hall, Per;Halyard, Michele
关键词：
目的探讨癌症相关性疲劳（cancer-related fatigue， CRF），探讨其潜在的生物学和遗传致病机制。目标是：(1)将生活质素描述为生活质素的一个组成部分；(2)解决测量问题，减缓了对这一症状背后机制的理解；(3)综述了研究CRF发病机制的生物学途径和遗传学方法；(4)提出未来研究方向。方法回顾、综合和解释文献。结果直到最近，CRF和QOL主要被理解为患者报告的主观体验。随着对人类遗传学了解的增加，理论和研究正在扩大，以纳入对这些主观经验的生物学和遗传学理解。已研究的CRF的生物学和遗传机制包括细胞因子失调、下丘脑-垂体-肾上腺（HPA）轴功能障碍、5-羟色氨酸（5-HT）神经递质失调、昼夜节律紊乱、三磷酸腺苷（ATP）和肌肉代谢的改变以及迷走神经传入激活。研究遗传机制的方法也包括候选基因、全基因组扫描和基因表达。在回顾和综合文献的基础上，提出了今后的研究方向。结论了解CRF的生物学和遗传学基础有助于更全面地了解生活质量的遗传决定因素。
ObjectiveThe goal of this paper is to discuss cancer-related fatigue (CRF) and address issues related to the investigation into potential biological and genetic causal mechanisms. The objectives are to: (1) describe CRF as a component of quality of life (QOL); (2) address measurement issues that have slowed progress toward an understanding of mechanisms underlying this symptom; (3) review biological pathways and genetic approaches that have promise for the exploration of causal mechanisms of CRF; and (4) offer directions for future research.MethodsReview, synthesis, and interpretation of the literature.ResultsUntil recently, CRF and QOL have been understood primarily as subjective patient-reported experiences. With increased understanding of human genetics, theories and research are being expanded to incorporate biological and genetic understandings of these subjective experiences. Proposed biological and genetic mechanisms of CRF that have been examined include cytokine dysregulation, hypothalamic–pituitary–adrenal (HPA) axis dysfunction, five hydroxy tryptophan (5-HT) neurotransmitter dysregulation, circadian rhythm disruption, alterations in adenosine triphosphate (ATP) and muscle metabolism, and vagal afferent activation. Approaches to the study of genetic mechanisms have also been addressed including candidate genes, genome-wide scanning, and gene expression. Based on the review and synthesis of the literature, directions for future research are proposed.ConclusionsUnderstanding the biological and genetic basis of CRF has the potential to contribute to a more complete understanding of the genetic determinants of QOL.
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影响因子：
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作者：
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