Absorptive clearance of DTPA as an aerosol-based biomarker in the cystic fibrosis airway.
Absorptive clearance of DTPA as an aerosol-based biomarker in the cystic fibrosis airway.
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DOI：
10.1183/09031936.00059009
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Pilewski JM
中科院分区：
文献类型：
--
作者：
Corcoran TE;Thomas KM;Myerburg MM;Muthukrishnan A;Weber L;Frizzell R;Pilewski JM
Biomarkers providing in vivo quantification of the basic elements of CF lung disease are needed. We questioned whether the absorption of a small, radiolabeled, hydrophilic molecule (Indium 111 DTPA) would be increased in CF airways. DTPA clearance has been used previously to assess epithelial permeability and may also be useful for quantifying liquid absorption. The absorptive clearance rate of DTPA was quantified in 10 CF and 11 control subjects using a novel aerosol technique. Subjects inhaled an aerosol containing non-absorbable Technetium-99m sulfur colloid (Tc-SC) particles and Indium-111 DTPA (In-DTPA). Tc-SC clearance from the lung is exclusively mucociliary while In-DTPA is cleared by both absorption and mucociliary clearance. The difference between the In-DTPA and Tc-SC clearance rates estimates In-DTPA absorption. Tc-SC (mucociliary) clearance was similar in central and peripheral zones in CF and non-CF. Total In-DTPA clearance was increased in both zones in CF. The absorptive component of In-DTPA clearance was increased in the airway-dominated central lung zones in CF (42 vs. 32 %/hr, p=0.03). The absorption of In-DTPA is increased in the CF airway. Further study is needed to understand the relative roles of fluid absorption, inflammation, and other mechanisms potentially affecting epithelial permeability and DTPA absorption.
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影响因子：
3.3
作者：
Coates, G;O'Brodovich, H;Dolovich, M
通讯作者：
Dolovich, M
DOI：
10.1513/pats.200703-042br
发表时间：
2007-08-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Donaldson, Scott H;Corcoran, Timothy E;Bennett, William D
通讯作者：
Bennett, William D
DOI：
10.1513/pats.200703-040br
发表时间：
2007-08-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Mayer-Hamblett, Nicole;Ramsey, Bonnie W;Kronmal, Richard A
通讯作者：
Kronmal, Richard A
影响因子：
3.3
作者：
WELLS, UM;WOODS, AJ;WIDDICOMBE, JG
通讯作者：
WIDDICOMBE, JG
影响因子：
24.3
作者：
Robinson, M;Daviskas, E;Bye, PTP
通讯作者：
Bye, PTP