Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages
Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages
复制标题
鼠丝虫病：白细胞介素 4 和白细胞介素 5 导致不同蠕虫发育阶段的遏制
DOI：
--
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
A. Hoerauf
中科院分区：
文献类型：
--
作者：
L. Volkmann;O. Bain;M. Saeftel;S. Specht;K. Fischer;F. Brombacher;K. Matthaei;A. Hoerauf
抽象的。我们比较了 BALB/c 小鼠完全允许感染啮齿动物丝虫乙状丝虫期间 IL-4 和 IL-5 缺乏的影响。与 IL-4 相比，IL-5 对于短期和长期感染期间抑制成虫至关重要。 IL-5 KO小鼠允许更多的幼虫发育成成虫，并且在慢性感染期间（感染后第60天至200天）持续存在的成虫数量增加了200倍。这种持续性的增加伴随着成虫丝虫周围炎症结节的减少。相比之下，BALB/c野生型小鼠和BALB/c IL-4 KO或BALB/c IL-4受体（IL-4R）α链KO小鼠之间成虫存活率和结节形成没有差异。与野生型小鼠相比，IL-4 和 IL-5 KO 小鼠的微丝蚴血症大大增强（160 倍）并延长。这种对微丝蚴的易感性需要在整个感染周期中存在成虫，因为单独腹腔注射微丝蚴后，它们会以相同的动力学从 BALB/c、BALB/c IL-4 KO 和 BALB/c IL-4R α-链 KO 小鼠中去除，并且因为 IL-5 KO 小鼠中的微丝蚴存活率仅略有增加（完全感染时为 5 倍，相对于 160 倍）。总之，IL-4和IL-5依赖性效应途径针对丝虫的不同阶段起作用，并且IL-5对寄生虫遏制的影响比IL-4更大。
Abstract. We compared the impact of IL-4 and IL-5 deficiency during the fully permissive infection of BALB/c mice with the rodent filaria Litomosoides sigmodontis. IL-5, in contrast to IL-4, is crucial for the containment of adult worms during short- and long-term infections. IL-5 KO mice allowed development of more larvae into adult worms and showed up to 200 times more adult worms persisting during chronic infection (day 60 until 200 post-infection). This increased persistence was accompanied by a reduction in inflammatory nodules around adult filariae. In contrast, adult worm survival and nodule formation did not differ between BALB/c wild-type mice and BALB/c IL-4 KO or BALB/c IL-4 receptor (IL-4R) α-chain KO mice. In both IL-4 and IL-5 KO mice microfilaraemia was greatly enhanced (160-fold) and prolonged compared to wild-type mice. This extent of susceptibility to microfilariae required the presence of adult worms in a full infection cycle since upon intraperitoneal injection of microfilariae alone they were removed from BALB/c, BALB/c IL-4 KO and BALB/c IL-4R α-chain KO mice with equivalent kinetics, and since microfilarial survival was only slightly increased in IL-5 KO mice (factor of 5 vs. factor of 160 in full infection). In conclusion, IL-4 and IL-5 dependent effector pathways operate against different stages of filarial worms, and IL-5 has a greater impact on parasite containment than IL-4.
曼氏血吸虫：IL-4 缺陷小鼠的保护性免疫。
DOI：
10.1006/expr.1996.0110
发表时间：
1996
期刊：
Experimental parasitology.
影响因子：
--
作者：
King,CL;Malhotra,I;Jia,X
通讯作者：
Jia,X
DOI：
10.1016/s0167-5699(05)80018-0
发表时间：
1991-03-01
期刊：
IMMUNOPARASITOLOGY TODAY-A COMBINED ISSUE OF IMMUNOLOGY TODAY AND PARASITOLOGY TODAY
影响因子：
--
作者：
FINKELMAN, FD;PEARCE, EJ;SHER, A
通讯作者：
SHER, A