Exosomes in Parkinson disease.
Exosomes in Parkinson disease.
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DOI：
10.1111/jnc.15288
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发表时间：
2021-05
影响因子：
4.7
通讯作者：
Tieu K
中科院分区：
文献类型：
--
作者：
Pinnell JR;Cui M;Tieu K
帕金森病（Parkinson disease，PD）是一种常见的神经退行性疾病，其中α-突触核蛋白的错误折叠和聚集是其重要的神经病理学标志。最近的研究表明，细胞外囊泡如外来体是病理性α-突触核蛋白在整个大脑中传播的潜在机制。外泌体在细胞之间转运蛋白质和遗传物质的能力，包括与PD病理学有关的mRNA和microRNA，为外泌体如何促进PD的病理学进展提供了重要的见解。外泌体作为调节帕金森病病理学的潜在工具的研究也取得了进展;它们的细胞外检测可能有助于它们作为生物标志物的使用，而它们的小尺寸可以用作递送治疗剂的载体。本文综述的目的是突出我们目前对外泌体在PD中的作用和潜在的临床应用的认识。
Parkinson disease (PD) is a prevalent neurodegenerative disease, in which the formation of misfolded and aggregated α-synuclein is a key neuropathological hallmark. Recent studies reveal that extracellular vesicles such as exosomes present a potential mechanism for propagation of pathological α-synuclein throughout the brain. The ability of exosomes to transport proteins and genetic material between cells, including mRNA and microRNAs which have been implicated in PD pathology, provides critical insights as to how exosomes may contribute to pathological progression in PD. Advances have also been made in the investigation of exosomes as potential tools for the modulation of Parkinson’s pathology; their detection extracellularly may facilitate their use as biomarkers, whilst their small size could be utilised as vectors for the delivery of therapeutics. The aim of this review is to highlight our current knowledge of the role of exosomes in PD and potential clinical application.
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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