Cytomegalovirus isolation from healthy homosexual men.

Cytomegalovirus isolation from healthy homosexual men.
复制标题

从健康同性恋男性中分离出巨细胞病毒。

DOI：
10.1001/jama.1984.03350140054026
复制
发表时间：
1984
期刊：
JAMA
影响因子：
--
通讯作者：
M. Grieco
M. Grieco
中科院分区：
--
文献类型：
--
作者：
M. Lange;E. Klein;H. Kornfield;L. Cooper;M. Grieco

文献摘要

参考文献

被引文献

相似文献

获得性免疫缺陷综合征（AIDS）引起了人们对巨细胞病毒（CMV）的新的关注，CMV既是AIDS的感染性并发症，也是免疫抑制发病机制中的潜在病原体。我们研究了纽约市的30名健康男同性恋者，以确定病毒排泄的流行率及其与CMV-IgM抗体和T淋巴细胞亚群的关系。在11例受试者的尿液和/或精液中检测到巨细胞病毒。11例CMV散毒者中8例CMV-IgM阳性，19例未散毒者中仅1例CMV-IgM阳性。虽然同性恋者作为一个群体，其OKT 4/OKT 8比值（0.8 +/- 0.4，平均值+/- SD）低于异性恋对照组（1.8 +/- 0.4，平均值+/- SD），但排泄病毒的同性恋者与不排泄病毒的同性恋者之间的比值没有显著差异。男性同性恋者的巨细胞病毒排泄似乎比以前认识到的更普遍，可能构成性传播的重大风险。
The acquired immune deficiency syndrome (AIDS) has focused renewed interest on cytomegalovirus (CMV) both as an infectious complication of the syndrome and as a potential etiologic agent in the pathogenesis of the immunosuppression. We studied 30 healthy homosexual men in New York City to determine the prevalence of virus excretion and its relationship to CMV-IgM antibodies and to T-lymphocyte subsets. Cytomegalovirus was detected in the urine and/or semen of 11 subjects. Eight of 11 CMV shedders were CMV-IgM positive, but CMV IgM was found in only one of 19 not shedding the virus. While homosexuals as a group had lower OKT4/OKT8 ratios (0.8 +/- 0.4, mean +/- SD) than heterosexual controls (1.8 +/- 0.4, mean +/- SD), there was no significant difference in ratios between homosexuals excreting virus and those not excreting virus. Cytomegalovirus excretion by homosexual men seems to be more prevalent than previously appreciated and may pose a significant risk for sexual transmission.
Analysis of T lymphocyte subsets in cytomegalovirus mononucleosis.
巨细胞病毒单核细胞增多症中 T 淋巴细胞亚群的分析。
DOI： --
发表时间： 1981
期刊： Journal of immunology (Baltimore, Md. : 1950)
影响因子： --
作者：
Carney,WP;Rubin,RH;Hoffman,RA;Hansen,WP;Healey,K;Hirsch,MS
通讯作者： Hirsch,MS
Acquired immunodeficiency syndrome, opportunistic infections, and malignancies in male homosexuals. A hypothesis of etiologic factors in pathogenesis.
男性同性恋者的获得性免疫缺陷综合征、机会性感染和恶性肿瘤。
DOI： --
发表时间： 1983
期刊： JAMA : the journal of the American Medical Association
影响因子： --
作者：
Sonnabend,J;Witkin,SS;Purtilo,DT
通讯作者： Purtilo,DT
T-lymphocyte subpopulations in patients with classic hemophilia treated with cryoprecipitate and lyophilized concentrates.
用冷沉淀和冻干浓缩物治疗的经典血友病患者的 T 淋巴细胞亚群。
DOI： 10.1056/nejm198301133080206
发表时间： 1983
期刊： The New England journal of medicine
影响因子： --
作者：
Menitove,JE;Aster,RH;Casper,JT;Lauer,SJ;Gottschall,JL;Williams,JE;Gill,JC;Wheeler,DV;Piaskowski,V;Kirchner,P;Montgomery,RR
通讯作者： Montgomery,RR