Telomere attrition, kidney function, and prevalent chronic kidney disease in the United States.
Telomere attrition, kidney function, and prevalent chronic kidney disease in the United States.
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DOI：
10.18632/oncotarget.20706
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发表时间：
2017-10-06
期刊：
影响因子：
--
通讯作者：
Banach M
中科院分区：
文献类型：
--
作者：
Mazidi M;Rezaie P;Covic A;Malyszko J;Rysz J;Kengne AP;Banach M
端粒长度是一种新兴的生物年龄、心血管风险和慢性疾病的生物标志物。很少有研究关注端粒长度(TL)和肾功能之间的关系。我们在美国成年人中调查了TL与肾功能/流行的慢性肾脏疾病(CKD)之间的关系。研究对象包括1999年至2002年的国家健康与营养调查(NHANES)参与者的肾功能和TL的测量数据。估计的肾小球滤过率(EGFR)基于CKD流行病学协作(CKD-EPI)方程。用尿白蛋白/肌酐比值(ACR)评估尿白蛋白排泄量。我们使用了多变量调整的线性和Logistic回归模型，考虑了调查设计和样本权重。在10568名符合条件的参与者中，48.0%(n=5020)为男性。他们的平均年龄为44.1岁。在TL增长的几个季度中，EGFR显著降低，ACR显著增加(均为P<；0.001)。即使在调整了潜在的混杂因素后，TL和肾功能之间的关联仍然很强，但TL和ACR之间的关联只是边缘显著的(β系数=-0.012，p=0.056)。肾功能与细胞衰老标记物的关联提示了影响肾病进展的潜在机制。
Telomere length is an emerging novel biomarker of biologic age, cardiovascular risk and chronic medical conditions. Few studies have focused on the association between telomere length (TL) and kidney function. We investigated the association between TL and kidney function/prevalent chronic kidney disease (CKD) in US adults. The National Health and Nutrition Examination Survey (NHANES) participants with measured data on kidney function and TL from 1999 to 2002 were included. Estimated glomerular filtration rate (eGFR) was based on CKD Epidemiology Collaboration (CKD-EPI) equation. Urinary albumin excretion was assessed using urinary albumin-creatinine ratio (ACR). We used multivariable adjusted linear and logistic regression models, accounting for the survey design and sample weights. Of the 10568 eligible participants, 48.0% (n=5020) were men. Their mean age was 44.1 years. eGFR significantly decreased and ACR significantly increased across increasing quarters of TL (all p<0.001). The association between TL and kidney function remained robust even after adjusting for potential confounding factors, but the association between TL and ACR was only borderline significant (β-coefficient= -0.012, p=0.056). The association of kidney function with a marker of cellular senescence suggests an underlying mechanism influencing the progression of nephropathy.
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影响因子：
4.2
作者：
Bansal N;Whooley MA;Regan M;McCulloch CE;Ix JH;Epel E;Blackburn E;Lin J;Hsu CY
通讯作者：
Hsu CY
慢性肾脏疾病患者动脉粥样硬化风险增加的标记：初步研究。
影响因子：
4.5
作者：
Gluba-Brzózka A;Michalska-Kasiczak M;Franczyk B;Nocuń M;Toth P;Banach M;Rysz J
通讯作者：
Rysz J
影响因子：
14.9
作者：
Cawthon RM
通讯作者：
Cawthon RM
影响因子：
2.3
作者：
Luttropp K;Nordfors L;McGuinness D;Wennberg L;Curley H;Quasim T;Genberg H;Sandberg J;Sönnerborg I;Schalling M;Qureshi AR;Bárány P;Shiels PG;Stenvinkel P
通讯作者：
Stenvinkel P
DOI：
10.1093/gerona/glp049
发表时间：
2009-07-01
影响因子：
5.1
作者：
Maeda, Toyoki;Guan, Jing Zhi;Makino, Naoki
通讯作者：
Makino, Naoki