Negative symptoms in individuals at clinical high risk of psychosis.
Negative symptoms in individuals at clinical high risk of psychosis.
复制标题
临床高精神病风险的个体的负面症状。
DOI：
10.1016/j.psychres.2012.02.018
复制
发表时间：
2012-04-30
影响因子：
11.3
通讯作者：
McGlashan, Thomas H.
中科院分区：
文献类型：
--
作者：
Piskulic, Danijela;Addington, Jean;Cadenhead, Kristin S.;Cannon, Tyrone D.;Cornblatt, Barbara A.;Heinssen, Robert;Perkins, Diana O.;Seidman, Larry J.;Tsuang, Ming T.;Walker, Elaine F.;Woods, Scott W.;McGlashan, Thomas H.
阴性症状出现在精神病前驱症状中。然而，在精神病第一次发作之前，这些症状出现的程度仍然没有得到充分的研究。这项研究的目的是检查精神病临床高危人群样本中的阴性症状，并确定它们是否预示着转化为精神病。参与者(n=138)都是北美前驱症状纵向研究(NAPLS 1)项目的参与者。阴性症状采用前驱症状量表进行纵向评定。基线的平均总阴性症状评分为11.0，82.0%的样本至少有一项阴性症状的评分达到中等或以上。在12个月的过程中，54.0%的参与者的症状保持在上述中等严重程度范围内。个体症状之间的相关性为中等(r=0.31tor=0.57P<；0.001)，因素分析证实，所有阴性症状都严重集中在一个因素上。在转化为精神病者中，阴性症状更严重，持续时间更长，预测转化的可能性(χ2=17.63，df=6，P<；0.01，R2=0.21)。因此，早期和持续的阴性症状可能代表着发展成精神病的风险的脆弱性。
Negative symptoms are present in the psychosis prodrome. However, the extent to which these symptoms are present prior to the onset of the first episode of psychosis remains under-researched. The goal of this study is to examine negative symptoms in a sample of individuals at clinical high risk (CHR) for psychosis and to determine if they are predictive of conversion to psychosis. Participants (n=138) were all participants in the North American Prodrome Longitudinal Study (NAPLS 1) project. Negative symptoms were assessed longitudinally using the Scale of Prodromal Symptoms. The mean total negative symptom score at baseline was 11.0, with 82.0% of the sample scoring at moderate severity or above on at least one negative symptom. Over the course of 12 months, the symptoms remained in the above moderate severity range for 54.0% of participants. Associations between individual symptoms were moderate (r= 0.31 to r= 0.57, P<0.001) and a factor analysis confirmed that all negative symptoms loaded heavily on one factor. Negative symptoms were more severe and persistent over-time in those who converted to psychosis, predicting the likelihood of conversion (χ2 = 17.63, df= 6, P< 0.01, R2 = 0.21). Thus, early and persistent negative symptoms may represent a vulnerability for risk of developing psychosis.
登录
查看更多内容
影响因子：
3.8
作者：
Faerden, Ann;Friis, Svein;Melle, Ingrid
通讯作者：
Melle, Ingrid
影响因子：
6.9
作者：
Addington, J;Young, J;Addington, D
通讯作者：
Addington, D
社交厌恶症是精神分裂症谱系障碍发展的一个预测因素
影响因子：
4.6
作者：
Kwapil, TR
通讯作者：
Kwapil, TR
影响因子：
10.5
作者：
Johnstone, EC;Ebmeier, KP;Lawrie, SM
通讯作者：
Lawrie, SM
影响因子：
4.5
作者：
Yung, AR;Phillips, LJ;McGorry, PD
通讯作者：
McGorry, PD