Virome of US bovine calf serum.

Virome of US bovine calf serum.
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DOI:
10.1016/j.biologicals.2016.12.009
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发表时间:
2017-03
期刊:
Biologicals : journal of the International Association of Biological Standardization
影响因子:
--
通讯作者:
Delwart E
Delwart E
中科院分区:
其他
文献类型:
--
作者:
Sadeghi M;Kapusinszky B;Yugo DM;Phan TG;Deng X;Kanevsky I;Opriessnig T;Woolums AR;Hurley DJ;Meng XJ;Delwart E

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Using viral metagenomics we analyzed four serum pools assembled from 715 calves in the United States. Two parvoviruses, bovine parvovirus 2 (BPV2) and a previously uncharacterized parvovirus designated as bosavirus (BosaV), were detected in 3 and 4 pools respectively and their complete coding sequences generated. Based on NS1 protein identity, bosavirus qualifies as a member of a new species in the copiparvovirus genus. Also detected were low number of reads matching ungulate tetraparvovirus 2, bovine hepacivirus, and several human papillomaviruses. This study further characterizes the diversity of viruses in calf serum with the potential to infect fetuses and through fetal bovine serum contaminate cell cultures.
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