Insulin-stimulated protein kinase activity in rat skeletal muscle that phosphorylates ribosomal protein S6.

Insulin-stimulated protein kinase activity in rat skeletal muscle that phosphorylates ribosomal protein S6.
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大鼠骨骼肌中胰岛素刺激的蛋白激酶活性使核糖体蛋白 S6 磷酸化。

DOI:
10.1016/s0006-291x(88)80412-1
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发表时间:
1988
影响因子:
3.1
通讯作者:
Straus,DS
Straus,DS
中科院分区:
生物学4区
文献类型:
--
作者:
Hecht,LB;Straus,DS

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Treatment of rats with a single high dose of insulin leads to rapid stimulation of cytosolic protein kinase activity in skeletal muscle that phosphorylates ribosomal protein S6. This stimulation is maximal within 15 minutes after insulin treatment, and the activity remains elevated for at least 90 minutes. The insulin-stimulated protein kinase activity elutes as two peaks from DEAE-Sepharose. Peak I elutes at 0.04–0.06 M KCl and is stimulated by insulin approximately 1.4-fold above the control. Peak II elutes at 0.09–0.11 M KCl and is stimulated 2.8-fold above the control. The peak II activity, which is most strongly stimulated by insulin, is resolved from cyclic AMP-dependent protein kinase on DEAE-Sepharose and appears to be distinct from protein kinase C. These results represent a novel finding of the stimulation of S6 kinase activity by insulin in skeletal muscle tissuein vivo.
DOI: 10.1016/s0021-9258(17)42478-1
发表时间: 1986-01
期刊: The Journal of biological chemistry
影响因子: --
作者:
E. Erikson;J. Maller
通讯作者: E. Erikson;J. Maller
钙激活的磷脂依赖性蛋白激酶在哺乳动物组织中广泛存在。
DOI: --
发表时间: 1981
期刊: Journal of Biochemistry (Tokyo)
影响因子: --
作者:
R. Minakuchi;Y. Takai;Binzu Yu;Yasutomi Nishizuka
通讯作者: Yasutomi Nishizuka
[6] cAMP依赖性蛋白激酶的催化亚基
DOI: --
发表时间: 1983
期刊:
影响因子: --
作者:
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大鼠肝脏再生过程中激活的 S6 激酶。
DOI: --
发表时间: 1987
期刊: Biochemical and Biophysical Research Communications - BBRC
影响因子: --
作者:
K. Mizuta;E. Hashimoto;Y. Sakanoue;S. Nakamura;H. Kondo;H. Yamamura
通讯作者: H. Yamamura
来自大鼠脑的钙激活、磷脂依赖性蛋白激酶(蛋白激酶 C)。
DOI: --
发表时间: 1983
影响因子: --
作者:
U. Kikkawa;R. Minakuchi;Y. Takai;Y. Nishizuka
通讯作者: Y. Nishizuka