Unravelling staphylococcal small-colony variants in cardiac implantable electronic device infections: clinical characteristics, management, and genomic insights.
Unravelling staphylococcal small-colony variants in cardiac implantable electronic device infections: clinical characteristics, management, and genomic insights.
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DOI：
10.3389/fcimb.2023.1321626
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发表时间：
2023
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
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作者：
葡萄球菌小菌落变异体（SCV）在心脏植入式电子设备（CIED）感染中很常见。这是首次对葡萄球菌SCV引起的CIED感染进行回顾性多病例研究，旨在为葡萄球菌SCV引起的CIED和器械相关感染的临床管理提供理论依据。2021年至2022年期间入组了90名培养阳性CIED感染患者。我们比较了有和没有SCV的患者的人口统计学和临床特征，并对SCV分离株进行了基因组研究。与无SCV的患者相比，有SCV的患者的初次起搏器植入时间更长，更可能有器械更换和感染史。他们的炎症指标上调，尤其是NEUT%更高（52.6 vs. 26.8%，P = 0.032），住院时间更长（中位数13 vs. 12天，P = 0.012）。对表皮葡萄球菌野生型和SCV进行比较基因组学分析。鉴定了一些基因，包括aap、编码粘附素的基因、含锚定结构域的蛋白、含LPXTG细胞壁锚结构域的蛋白和含YSIRK型信号肽的蛋白。葡萄球菌SCV影响CIED感染的临床特征。葡萄球菌SCV粘附、生物膜形成和与中性粒细胞相互作用的过程起着至关重要的作用。
Staphylococcal small-colony variants (SCVs) are common in cardiac implantable electronic device (CIED) infections. This is the first retrospective and multi-case study on CIED infections due to staphylococcal SCVs, aiming to provide a theoretical basis for the clinical management of CIED and device-related infections caused by staphylococcal SCVs. Ninety patients with culture positive CIED infections were enrolled between 2021 and 2022. We compared the demographic and clinical characteristics of patients with and without SCVs and performed genomic studies on SCVs isolates. Compared to patients without SCVs, those with SCVs had a longer primary pacemaker implantation time and were more likely to have a history of device replacement and infection. They showed upregulated inflammatory indicators, especially higher NEUT% (52.6 vs. 26.8%, P = 0.032) and they had longer hospital stays (median 13 vs. 12 days, P = 0.012). Comparative genomics analysis was performed on Staphylococcus epidermidis wild-type and SCVs. Some genes were identified, including aap, genes encoding adhesin, CHAP domain-containing protein, LPXTG cell wall anchor domain-containing protein, and YSIRK-type signal peptide-containing protein. Staphylococcal SCVs affect the clinical characteristics of CIED infections. The process of staphylococcal SCVs adherence, biofilm formation, and interaction with neutrophils play a vital role.
影响因子：
14.9
作者：
Larson MA;Griep MA;Bressani R;Chintakayala K;Soultanas P;Hinrichs SH
通讯作者：
Hinrichs SH