Immunohistochemical localization of Nrf2 in the human cochlea.
Immunohistochemical localization of Nrf2 in the human cochlea.
复制标题
DOI：
10.1016/j.brainres.2018.07.004
复制
发表时间：
2018-12-01
期刊：
影响因子：
2.9
通讯作者：
Lopez IA
中科院分区：
文献类型：
--
作者：
Hosokawa K;Hosokawa S;Ishiyama G;Ishiyama A;Lopez IA
氧化应激在几种内耳疾病和正常衰老中起着重要作用。核（红细胞衍生2）样2，也称为Nrf 2，是一种由NFE 2L 2基因编码的转录因子，其控制减少氧化应激所必需的基因的表达。迄今为止，还没有关于正常或病理条件下Nrf 2在人内耳中的定位的研究。因此，我们使用福尔马林固定的纤维素包埋的人颞骨切片研究了Nrf 2在人耳蜗和前庭中的免疫组织化学定位。Nrf 2免疫反应阳性细胞分布于耳蜗Corti器的内、外毛细胞和支持细胞。Nfr 2-IR也见于前庭感觉上皮黄斑和嵴的毛细胞和支持细胞。Nrf 2-IR在老年人的Corti器官中降低。Nrf 2在听觉和前庭感觉上皮中的免疫定位表明，这种转录因子可能在保护感觉毛细胞免受氧化应激中发挥相关作用。
Oxidative stress plays an important role in several inner ear diseases and normal aging. Nuclear (erythroid-derived 2)-like 2, also known as Nrf2, is a transcription factor encoded by the NFE2L2 gene that controls the expression of genes necessary to reduce oxidative stress. There are no studies to the date on the localization of Nrf2 in the human inner ear in normal or pathological conditions. Therefore, we investigated the immunohistochemical localization of Nrf2 in the human cochlea and vestibule using formalin-fixed celloidin-embedded human temporal bone sections. Nrf2 immunoreactivity (IR) was found in the inner and outer hair cells and supporting cells of the organ of Corti throughout the cochlea. Nfr2-IR was also found in hair cells and supporting cells of the maculae and cristae vestibular sensory epithelia. Nrf2-IR was decreased in the organ of Corti of older age individuals. The immunolocalization of Nrf2 in both auditory and vestibular sensory epithelia suggest that this transcription factor may play a relevant role in protecting sensory hair cells from oxidative stress.
登录
查看更多内容
影响因子：
2.9
作者：
Nguyen, Kimanh D.;Mowlds, Donald;Lopez, Ivan A.;Hosokawa, Seiji;Ishiyama, Akira;Ishiyama, Gail
通讯作者：
Ishiyama, Gail
影响因子：
12.8
作者：
Kim, Se-Jin;Hur, Joon Ho;Park, Channy;Kim, Hyung-Jin;Oh, Gi-Su;Lee, Joon No;Yoo, Su-Jin;Choe, Seong-Kyu;So, Hong-Seob;Lim, David J.;Moon, Sung K.;Park, Raekil
通讯作者：
Park, Raekil
影响因子：
4.2
作者：
Kong, Li;Chen, Guang-Di;Zhou, Xiaohong;McGinnis, James F.;Li, Feng;Cao, Wei
通讯作者：
Cao, Wei
影响因子：
3.3
作者：
通讯作者：
--
DOI：
10.1002/ar.22622
发表时间：
2013-02-01
影响因子：
2
作者：
Balaker, Ashley E.;Ishiyama, Paul;Ishiyama, Akira
通讯作者：
Ishiyama, Akira