Simultaneous dual-band spectral domain optical coherence tomography using a supercontinuum laser light source

Simultaneous dual-band spectral domain optical coherence tomography using a supercontinuum laser light source
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使用超连续谱激光光源的同步双波段谱域光学相干断层扫描

DOI:
10.1117/12.831840
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发表时间:
2009
期刊:
影响因子:
6
通讯作者:
E. Koch
E. Koch
中科院分区:
医学1区
文献类型:
--
作者:
P. Cimalla;M. Mehner;M. Cuevas;J. Walther;E. Koch

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光学相干断层扫描 (OCT) 在光谱域中同时在以 800 nm 和 1250 nm 为中心的两个不同波长带上进行。新型商用超连续谱激光器被用作单光源,其发射光谱通过光学和空间滤波进行整形,以获得足够的双峰光谱。光谱整形后,700 - 900 nm 和 1100 - 1400 nm 波段用于 OCT 成像。针对两个光谱区域进行优化的光纤耦合设置有助于轻松灵活地访问测量区域。每个波长带均使用单独的光谱仪以约 12 kHz 的 A 扫描速率进行分析,从而可以进行实时样品检查。在 800 nm 和 1250 nm 处测得自由空间轴向分辨率分别小于 4.5 μm 和 7 μm。该技术结合了 800 nm 的高分辨率和 1250 nm 的增强成像深度。此外,通过比较两个不同波段的后向散射特性来提取空间分辨光谱样本特征,显示了双波段 OCT 增强图像对比度的能力。
Optical coherence tomography (OCT) is performed in the spectral domain simultaneously at two different wavelength bands centered at 800 nm and 1250 nm. A novel commercial supercontinuum laser is applied as a single light source whose emission spectrum is shaped by optical and spatial filtering to obtain an adequate double peak spectrum. After spectral shaping, the wavelength bands 700 - 900 nm and 1100 - 1400 nm are used for OCT imaging. A fiber-coupled setup optimized for both spectral regions facilitates easy and flexible access to the measurement area. Each wavelength band is analyzed with an individual spectrometer at an A-scan rate of about 12 kHz which allows real-time sample examination. The free-space axial resolutions were measured to be less than 4.5 μm and 7 μm at 800 nm and 1250 nm, respectively. This technique combines the high resolution at 800 nm with the enhanced imaging depth at 1250 nm. Furthermore, spatially resolved spectroscopic sample features are extracted by comparing the backscattering properties at the two different wavelength bands, showing the ability of dual-band OCT to enhance image contrast.
使用提供多个光谱波段的独特光源研究 OCT 成像性能
DOI: 10.1117/12.766553
发表时间: 2008
期刊: --
影响因子: --
作者:
Cernat R
通讯作者: Cernat R
DOI: 10.1038/nbt892
发表时间: 2003-11-01
影响因子: 46.9
作者:
Fujimoto, JG
通讯作者: Fujimoto, JG