Alzheimer’s Model Develops Early ADHD Syndrome

Alzheimer’s Model Develops Early ADHD Syndrome
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阿尔茨海默病模型发展为早期多动症综合征

DOI:
10.4172/2155-9562.1000329
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发表时间:
2016
期刊:
Journal of neurology & neurophysiology
影响因子:
--
通讯作者:
D. Bredesen
D. Bredesen
中科院分区:
--
文献类型:
--
作者:
Qiang Zhang;Guiping Du;Varghese John;P. Kapahi;D. Bredesen

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我们描述了第一个注意力缺陷多动障碍(ADHD)的无脊椎动物模型,该模型再现了其主要特征,包括多动、男性主导、简单碳水化合物显着恶化、对右旋苯丙胺的可逆反应以及对兴奋剂的“矛盾反应”。该模型可能为 ADHD 发病机制和治疗提供新的见解。此外,鉴于最近的流行病学证据表明痴呆症患者有较高的先前 ADHD 症状,这些发现特别令人感兴趣。
We describe the first invertebrate model of attention deficit hyperactivity disorder (ADHD) that reproduces its major features, including hyperactivity, male predominance, marked exacerbation by simple carbohydrates, reversible response to dextroamphetamine, and a “paradoxical response” to stimulants. This model may offer new insight into ADHD pathogenesis and treatment. Furthermore, these findings are of particular interest in light of the recent epidemiological evidence showing that patients with dementia have a high frequency of antecedent ADHD symptoms.
DOI: 10.1016/j.cmet.2012.06.005
发表时间: 2012-07-03
期刊: Cell metabolism
影响因子: 29
作者:
Katewa SD;Demontis F;Kolipinski M;Hubbard A;Gill MS;Perrimon N;Melov S;Kapahi P
通讯作者: Kapahi P