Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster.
Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster.
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DOI：
10.1016/j.cmet.2012.06.005
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发表时间：
2012-07-03
期刊：
影响因子：
29
通讯作者：
Kapahi P
中科院分区：
文献类型：
--
作者：
Katewa SD;Demontis F;Kolipinski M;Hubbard A;Gill MS;Perrimon N;Melov S;Kapahi P
脂肪含量的变化与饮食限制（DR）有关，但它们是否在介导DR的各种反应中起因果作用尚不清楚。我们证明，在DR时，黑腹果蝇的代谢向增加脂肪酸合成和分解的方向转变，这是对DR的各种反应所必需的。肌肉组织中脂肪酸合成或氧化基因的抑制抑制了DR时果蝇的寿命延长。此外，DR增强了果蝇的自发活动，这依赖于增强的脂肪酸代谢。这种活性的增加至少在一定程度上是延长dr的寿命所必需的。脂肪运动激素（dAKH）的过度表达，胰高血糖素的功能同源物，增强脂肪代谢，自发活性和寿命。总之，这些结果表明，肌肉中脂肪代谢的增强和身体活动在DR的保护作用中发挥了关键作用。
Changes in fat content have been associated with dietary restriction (DR), but whether they play a causal role in mediating various responses to DR remains unknown. We demonstrate that upon DR, Drosophila melanogaster shift their metabolism towards increasing both fatty acid synthesis and breakdown, which is required for various responses to DR. Inhibition of fatty acid synthesis or oxidation genes specifically in the muscle tissue inhibited lifespan extension upon DR. Furthermore, DR enhances spontaneous activity of flies which was found to be dependent on the enhanced fatty acid metabolism. This increase in activity was found to be at least partially required for the lifespan extension upon DR. Over-expression of adipokinetic hormone (dAKH), the functional ortholog of glucagon, enhances fat metabolism, spontaneous activity and lifespan. Together, these results suggest that enhanced fat metabolism in the muscle and physical activity play a key role in the protective effects of DR.
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卡路里不能通过果蝇饮食限制来解释寿命的延长。
影响因子：
9.8
作者：
Mair, William;Piper, Matthew D W;Partridge, Linda
通讯作者：
Partridge, Linda
影响因子：
9.8
作者：
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64.5
作者：
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影响因子：
2.1
作者：
CHIPPINDALE, AK;LEROI, AM;ROSE, MR
通讯作者：
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影响因子：
9.2
作者：
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