Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan.
Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan.
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DOI：
10.1186/s12199-017-0681-0
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发表时间：
2017-10-24
影响因子：
4.7
通讯作者：
Katoh T
中科院分区：
文献类型：
--
作者：
Koda M;Iwasaki M;Yamano Y;Lu X;Katoh T
杂环芳香胺（哈斯）可能会导致前列腺癌的风险;然而，证据是不确定的，HAAs代谢酶的活性是由基因变异调节的。本研究的目的是确定是否有证据表明日本男性中HAA摄入量、NAT 2、CYP 1A 1和CYP 1A 2多态性与前列腺癌风险之间存在关联。对一项观察性病例对照研究进行了次要数据分析。在750例前列腺癌患者和870名健康对照者中，351例患者和351名年龄匹配的对照者被纳入分析。使用食物频率问卷估计HAA摄入量，并通过TaqMan实时PCR检测对基因型进行评分。根据受影响/控制状态进行Logistic回归分析。我们发现高HAA摄入量与前列腺癌风险增加显著相关（比值比（OR），1.90; 95%置信区间（95%CI），1.40-2.59）。在具有NAT 2慢乙酰化表型（OR，1.65; 95%CI，1.04-2.61）、CYP 1A 1 GA + GG基因型（OR，1.27; 95%CI，1.02-1.59）和CYP 1A 2 CA + AA基因型（OR，1.43; 95%CI，1.03-2.00）的个体中观察到前列腺癌风险增加。此外，CYP 1A 1 GA + GG基因型与低（OR，2.05; 95%CI，1.19-3.63）、中等（OR，1.72; 95%CI，1.07-2.76）和高（OR，2.86; 95%CI，1.83-4.47）HAA摄入组的癌症风险增加相关。我们的研究结果表明，高HAA摄入量是前列腺癌的一个危险因素，与HAA代谢酶相关的基因型可以调节风险的程度。
Heterocyclic aromatic amines (HAAs) may confer prostate cancer risk; however, the evidence is inconclusive and the activity of HAA-metabolizing enzymes is modulated by gene variants. The purpose of our study was to determine whether there was evidence of an association between HAA intake, polymorphisms in NAT2, CYP1A1, and CYP1A2 and prostate cancer risk in Japanese men. Secondary data analysis of an observational case control study was performed. Among 750 patients with prostate cancer and 870 healthy controls, 351 cases and 351 age-matched controls were enrolled for analysis. HAA intake was estimated using a food frequency questionnaire and genotypes were scored by TaqMan real-time PCR assay. Logistic regression analysis was conducted according to affected/control status. We found that high HAA intake was significantly associated with an increased risk of prostate cancer (odds ratio (OR), 1.90; 95% confidence interval (95% CI), 1.40–2.59). The increased risk of prostate cancer was observed among individuals with the NAT2 slow acetylator phenotype (OR, 1.65; 95% CI, 1.04–2.61), CYP1A1 GA + GG genotype (OR, 1.27; 95% CI, 1.02–1.59), and CYP1A2 CA + AA genotype (OR, 1.43; 95% CI, 1.03–2.00). In addition, CYP1A1 GA + GG genotypes were associated with increased cancer risk in low (OR, 2.05; 95% CI, 1.19–3.63), moderate (OR, 1.72; 95% CI, 1.07–2.76), and high (OR, 2.86; 95% CI, 1.83–4.47) HAA intake groups. Our results suggest that high HAA intake is a risk factor of prostate cancer, and genotypes related to HAA metabolic enzymes can modulate the degree of the risk.
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影响因子：
5.4
作者：
Bylsma LC;Alexander DD
通讯作者：
Alexander DD
影响因子：
2.3
作者：
Iwasaki, Motoki;Mukai, Tomomi;Tsugane, Shoichiro
通讯作者：
Tsugane, Shoichiro
DOI：
10.1016/0006-291x(92)91703-s
发表时间：
1992-06-30
影响因子：
3.1
作者：
MINCHIN, RF;REEVES, PT;KADLUBAR, FF
通讯作者：
KADLUBAR, FF
DOI：
10.1016/j.jfca.2009.07.004
发表时间：
2010-02-01
期刊：
Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems
影响因子：
--
作者：
Iwasaki M;Kataoka H;Ishihara J;Takachi R;Hamada GS;Sharma S;Le Marchand L;Tsugane S
通讯作者：
Tsugane S
影响因子：
7.1
作者：
Abid, Zaynah;Cross, Amanda J.;Sinha, Rashmi
通讯作者：
Sinha, Rashmi