Nutritional status of hemodialysis patients with secondary hyperparathyroidism.
Nutritional status of hemodialysis patients with secondary hyperparathyroidism.
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血液透析继发性甲状旁腺功能亢进症患者的营养状况。
DOI：
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
S. Draibe
中科院分区：
文献类型：
--
作者：
L. Rezende;L. Cuppari;A. Carvalho;M. Canziani;S. Manfredi;M. Cendoroglo;D. Sigulem;S. Draibe
继发性甲状旁腺功能亢进对慢性肾功能衰竭患者营养状况的影响尚未完全确定。因此，本研究的目的是比较继发性甲状旁腺功能亢进症和非继发性甲状旁腺功能亢进症血液透析患者的营养指标。将16例血清甲状旁腺激素(PTH)>420pg/ml的血液透析患者(甲状旁腺机能亢进症组)与16例血清甲状旁腺激素(PTH)在290 pg/ml~290 pg/ml之间的血液透析患者(对照组)进行性别、年龄、透析时间的配对。测定以下指标：人体测量指数(体重指数、皮褶厚度、上臂肌围和体脂)、4天食物日记、蛋白质分解率、生化指标(血尿素氮、血肌酐、白蛋白、离子钙、无机磷、血清碱性磷酸酶、甲状旁腺素、pH和HCO(3))和透析效率。我们没有观察到两组之间的人体测量指标的差异。只有钙摄入量在两组间有显著差异(甲状旁腺功能亢进组为307.9 mg/天，对照组为475.8 mg/天)。甲状旁腺功能亢进组蛋白质分解率高于对照组(1.3：0.9g·kg~(-1)·d~(-1)，P=0.08)。除血尿素氮(86.4vs 75.7 mg/dl)、碱性磷酸酶(175vs65U/L)和甲状旁腺素(898vs155pg/ml)外，其余生化指标组间差异均无统计学意义。甲状旁腺功能亢进组PTH与蛋白分解率(r=0.61；P&t；0.05)和透析时间(r=0.53；P<；0.05)呈正相关。考虑到所使用的指标，我们不能证明高水平甲状旁腺素对血液透析患者营养状况的有害影响。然而，间接证据表明，甲状旁腺素对蛋白质代谢有作用。
The repercussions of secondary hyperparathyroidism on the nutritional status of chronic renal failure patients have not been well established. Therefore, the aim of this study was to compare the nutritional indices of hemodialysis patients with and without secondary hyperparathyroidism. Sixteen hemodialysis patients with serum parathyroid hormone (PTH) levels higher than 420 pg/ml (hyperparathyroidism group) were matched for gender, age and length of dialysis treatment to 16 patients with serum PTH between 64 and 290 pg/ml (control group). The following parameters were assessed: anthropometric indices (body mass index, skinfold thickness, midarm muscle circumference and body fat), 4-day food diaries, protein catabolic rate, biochemical indices (blood urea nitrogen, serum creatinine, albumin, ionized calcium, inorganic phosphorus, serum alkaline phosphatase, PTH, pH and HCO(3)) and dialysis efficiency. We did not observe differences in the anthropometric indices between the two groups. Only calcium intake was significantly different between groups (307.9 mg/day for the hyperparathyroidism group vs 475.8 mg/day for the control group). Protein catabolic rate tended to be higher in the hyperparathyroidism group compared to the control group (1.3 vs 0.9 g kg(-1) day(-1); P = 0.08). Except for blood urea nitrogen (86.4 vs 75.7 mg/dl), alkaline phosphatase (175 vs 65 U/l) and PTH (898 vs 155 pg/ml), no other differences were found between groups in the biochemical indices studied. PTH was directly correlated with protein catabolic rate (r = 0.61; P<0.05) and length of dialysis (r = 0.53; P<0.05) only in the hyperparathyroidism group. Considering the indices used, we could not demonstrate the deleterious effect of high PTH levels on the nutritional status of hemodialysis patients. Indirect evidence, however, suggests an action of PTH on protein metabolism.
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能量摄入对维持性血液透析患者营养状况的影响。
影响因子：
19.6
作者：
Slomowitz,LA;Monteon,FJ;Grosvenor,M;Laidlaw,SA;Kopple,JD
通讯作者：
Kopple,JD
DOI：
10.1210/jcem.75.1.1619003
发表时间：
1992-07
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
L. Quarles;Bruce Lobaugh;G. Murphy
通讯作者：
L. Quarles;Bruce Lobaugh;G. Murphy
慢性肾功能衰竭进展期间的自发膳食蛋白质摄入量。
DOI：
10.1681/asn.v651386
发表时间：
1995
期刊：
Journal of the American Society of Nephrology : JASN
影响因子：
--
作者：
Ikizler,TA;Greene,JH;Wingard,RL;Parker,RA;Hakim,RM
通讯作者：
Hakim,RM
影响因子：
15.9
作者：
MITCH, WE;MEDINA, R;GOLDBERG, AL
通讯作者：
GOLDBERG, AL