Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function.
Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function.
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DOI：
10.1152/ajpheart.00606.2009
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Kohl P
中科院分区：
文献类型：
--
作者：
Bishop MJ;Plank G;Burton RA;Schneider JE;Gavaghan DJ;Grau V;Kohl P
磁共振成像技术的最新进展揭示了关于心脏组织解剖学复杂性的丰富信息。然而，将这种精细尺度结构细节忠实地转化为计算整个心室模型的方法仍处于起步阶段，因此，这种额外复杂性与心功能模拟的相关性尚未得到阐明。在这里，我们描述了由高分辨率MR数据（原始数据分辨率：43 × 43 × 36 μm）构建的兔心室高度详细的有限元计算模型（分辨率：~ 125 μm）的开发，包括分割过程（使用水平集方法的组合），相关解剖特征的识别，网格生成和肌细胞取向表示（使用基于规则的方法）。完全访问已完成的模型和MR数据。将模拟结果与基于相同图像构建的简化模型进行比较，但不包括更精细的解剖特征（血管/心内膜结构）。初步模拟表明，小梁的存在可以为激发提供捷径，导致模型之间起搏后激活的区域差异。在应用外场刺激时，心内膜结构产生了小规模的虚拟电极，这似乎保护了复杂模型中部分心内膜免受强极化的影响，而由血管和细胞外间隙引起的壁内虚拟电极似乎减少了心外膜的极化。在激波后，这些差异导致了在更简化的模型中没有观察到的新的激发波前的产生。此外，观察到尖/基区刺激恢复速率的整体差异，导致随后的心律失常发作的差异。总之，结构简化模型非常适合于大范围的心脏建模应用。然而，当微观尺度上的行为相关时，特别是在检查外部电刺激对组织电生理和心律失常诱导的影响时，可以看到重要的差异。这突出了组织解剖学详细模型在心功能研究中的实用性，特别是在未来的患者特异性建模中。
Recent advances in magnetic resonance (MR) imaging technology have unveiled a wealth of information regarding cardiac histoanatomical complexity. However, methods to faithfully translate this level of fine-scale structural detail into computational whole ventricular models are still in their infancy, and, thus, the relevance of this additional complexity for simulations of cardiac function has yet to be elucidated. Here, we describe the development of a highly detailed finite-element computational model (resolution: ∼125 μm) of rabbit ventricles constructed from high-resolution MR data (raw data resolution: 43 × 43 × 36 μm), including the processes of segmentation (using a combination of level-set approaches), identification of relevant anatomical features, mesh generation, and myocyte orientation representation (using a rule-based approach). Full access is provided to the completed model and MR data. Simulation results were compared with those from a simplified model built from the same images but excluding finer anatomical features (vessels/endocardial structures). Initial simulations showed that the presence of trabeculations can provide shortcut paths for excitation, causing regional differences in activation after pacing between models. Endocardial structures gave rise to small-scale virtual electrodes upon the application of external field stimulation, which appeared to protect parts of the endocardium in the complex model from strong polarizations, whereas intramural virtual electrodes caused by blood vessels and extracellular cleft spaces appeared to reduce polarization of the epicardium. Postshock, these differences resulted in the genesis of new excitation wavefronts that were not observed in more simplified models. Furthermore, global differences in the stimulus recovery rates of apex/base regions were observed, causing differences in the ensuing arrhythmogenic episodes. In conclusion, structurally simplified models are well suited for a large range of cardiac modeling applications. However, important differences are seen when behavior at microscales is relevant, particularly when examining the effects of external electrical stimulation on tissue electrophysiology and arrhythmia induction. This highlights the utility of histoanatomically detailed models for investigations of cardiac function, in particular for future patient-specific modeling.
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DOI：
10.1196/annals.1380.023
发表时间：
2006-01-01
期刊：
INTERACTIVE AND INTEGRATIVE CARDIOLOGY
影响因子：
--
作者：
Burton, Rebecca A. B.;Plank, Gernot;Kohl, Peter
通讯作者：
Kohl, Peter
影响因子：
20.1
作者：
LIU, DW;GINTANT, GA;ANTZELEVITCH, C
通讯作者：
ANTZELEVITCH, C
影响因子：
2.9
作者：
Clayton, Richard H.
通讯作者：
Clayton, Richard H.
影响因子：
3
作者：
Fernández, JJ;Li, S
通讯作者：
Li, S
影响因子：
20.1
作者：
Hooks, Darren A.;Trew, Mark L.;Smaill, Bruce H.
通讯作者：
Smaill, Bruce H.