High ratio of triglycerides to HDL-cholesterol predicts extensive coronary disease.
High ratio of triglycerides to HDL-cholesterol predicts extensive coronary disease.
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DOI：
10.1590/s1807-59322008000400003
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发表时间：
2008-08
期刊：
影响因子：
--
通讯作者：
Chagas AC
中科院分区：
文献类型：
--
作者：
da Luz PL;Favarato D;Faria-Neto JR Jr;Lemos P;Chagas AC
甘油三酯与高密度脂蛋白胆固醇（TG/HDL-c）的比值异常表明有致动脉粥样硬化的脂质谱和发生冠状动脉疾病的风险。研究血脂水平（特别是TG/HDL-c）与冠状动脉疾病程度之间的关系。高危患者（n = 374）提交的冠状动脉造影测量他们的血脂变量和冠状动脉疾病程度评分的弗里森格指数。受试者包括220名男性和154名女性，年龄57.2 ± 11.1岁，总胆固醇为210± 50.3 mg/dL，甘油三酯为173.8 ± 169.8 mg/dL，HDL-胆固醇（HDL-c）为40.1 ± 12.8 mg/dL，LDL-胆固醇（LDL-c）为137.3 ± 46.2 mg/dL，TG/HDL-c为5.1 ± 5.3，和6.6 ± 4.7的Friesinger指数。冠状动脉病变程度（根据Friesenger指数5和血脂水平（正常与异常）进行二分，以下指标具有统计学显著性：甘油三酯，比值比为2.02（1.31-3.1; p = 0.0018）; HDL-c，比值比2.21（1.42-3.43; p = 0.0005）; TG/HDL-c，比值比2.01（1.30-3.09; p = 0.0018）。然而，冠状动脉疾病程度与总胆固醇[1.25（0.82-1.91; p = 0.33）]或LDL-c [1.47（0.96-2.25; p = 0.0842）]之间的关系不显著。对于甘油三酯（p = 0.0017）、HDL-c（p = 0.0001）和TG/HDL-c（p = 0.0018），Friesinger > 4和脂质四分位数的线性趋势卡方具有统计学显著性，但对于总胆固醇（p = 0.393）或LDL-c（p = 0.0568）则无统计学显著性。通过logistic回归OR进行的多变量分析得出TG/HDL-c为1.3 ± 0.79（p = .0001），HDL-c为0.779 ± 0.074（p = .0001），LDL为1.234 ± 0.097（p = 0.03）。受试者工作特征曲线分析表明，只有TG/HDL-c和HDL-c可用于检测广泛的冠状动脉疾病，前者与疾病的相关性更强。虽然一些血脂变量与冠状动脉疾病的程度相关，但甘油三酯与HDL-胆固醇的比值与程度的相关性最强。
An abnormal ratio of triglycerides to HDL-cholesterol (TG/HDL-c) indicates an atherogenic lipid profile and a risk for the development of coronary disease. To investigate the association between lipid levels, specifically TG/HDL-c, and the extent of coronary disease. High-risk patients (n = 374) submitted for coronary angiography had their lipid variables measured and coronary disease extent scored by the Friesinger index. The subjects consisted of 220 males and 154 females, age 57.2 ± 11.1 years, with total cholesterol of 210± 50.3 mg/dL, triglycerides of 173.8 ± 169.8 mg/dL, HDL-cholesterol (HDL-c) of 40.1 ± 12.8 mg/dL, LDL-cholesterol (LDL-c) of 137.3 ± 46.2 mg/dL, TG/HDL-c of 5.1 ± 5.3, and a Friesinger index of 6.6 ± 4.7. The relationship between the extent of coronary disease (dichotomized by a Friesenger index of 5 and lipid levels (normal vs. abnormal) was statistically significant for the following: triglycerides, odds ratio of 2.02 (1.31–3.1; p = 0.0018); HDL-c, odds ratio of 2.21 (1.42–3.43; p = 0.0005); and TG/HDL-c, odds ratio of 2.01(1.30–3.09; p = 0.0018). However, the relationship was not significant between extent of coronary disease and total cholesterol [1.25 (0.82–1.91; p = 0.33)] or LDL-c [1.47 (0.96–2.25; p = 0.0842)]. The chi-square for linear trends for Friesinger > 4 and lipid quartiles was statistically significant for triglycerides (p = 0.0017), HDL-c (p = 0.0001), and TG/HDL-c (p = 0.0018), but not for total cholesterol (p = 0.393) or LDL-c (p = 0.0568). The multivariate analysis by logistic regression OR gave 1.3 ± 0.79 (p = .0001) for TG/HDL-c, 0.779 ± 0.074 (p = .0001) for HDL-c, and 1.234 ± 0.097 (p = 0.03) for LDL. Analysis of receiver operating characteristic curves showed that only TG/HDL-c and HDL-c were useful for detecting extensive coronary disease, with the former more strongly associated with disease. Although some lipid variables were associated with the extent of coronary disease, the ratio of triglycerides to HDL-cholesterol showed the strongest association with extent.
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影响因子：
168.9
作者：
Walldius, G;Jungner, I;Steiner, E
通讯作者：
Steiner, E
影响因子：
168.9
作者：
Yusuf, S;Hawken, S;Liu, LS
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Liu, LS
影响因子：
2.8
作者：
da Luz, PL;Cesena, FHY;Cerqueira, ES
通讯作者：
Cerqueira, ES
影响因子：
37.8
作者：
MANNINEN, V;TENKANEN, L;FRICK, MH
通讯作者：
FRICK, MH
影响因子：
4.8
作者：
MILLER, NE
通讯作者：
MILLER, NE