Working Memory for Signs with Poor Visual Resolution: fMRI Evidence of Reorganization of Auditory Cortex in Deaf Signers.
Working Memory for Signs with Poor Visual Resolution: fMRI Evidence of Reorganization of Auditory Cortex in Deaf Signers.
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DOI：
10.1093/cercor/bhaa400
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发表时间：
2021-06-10
期刊：
影响因子：
--
通讯作者：
Rudner M
中科院分区：
文献类型：
--
作者：
Andin J;Holmer E;Schönström K;Rudner M
刺激减弱会增加语音处理过程中的工作记忆负荷。我们研究了这是否适用于符号处理，如果适用，该机制是否涉及次级听觉皮层。我们进行了一项功能磁共振成像实验，其中 16 名聋哑早期手语者 (DES) 和 22 名听力正常的非手语者执行了一项基于手语的 n-back 任务，其中包含三个负载级别以及以高分辨率和低分辨率呈现的刺激。我们发现，随着负荷的增加和视觉分辨率的降低，行为表现会下降，但两种操作之间所涉及的神经生物学机制有所不同，并且对于两组来说都是如此。重要的是，正如预测的那样，负载操作伴随着额顶叶工作记忆网络的激活，而分辨率操作则导致颞叶和枕叶的激活。此外，我们发现了次级听觉皮层跨模式重组的证据：DES 在该区域和其他几个区域之间具有更强的激活和更强的连接性。我们得出的结论是，负载和刺激分辨率在视觉-语言领域具有不同的神经基础，这对当前的工作记忆模型有影响，并且对于 DES，当任务要求较低时，次级听觉皮层参与表征的结合。
Stimulus degradation adds to working memory load during speech processing. We investigated whether this applies to sign processing and, if so, whether the mechanism implicates secondary auditory cortex. We conducted an fMRI experiment where 16 deaf early signers (DES) and 22 hearing non-signers performed a sign-based n-back task with three load levels and stimuli presented at high and low resolution. We found decreased behavioral performance with increasing load and decreasing visual resolution, but the neurobiological mechanisms involved differed between the two manipulations and did so for both groups. Importantly, while the load manipulation was, as predicted, accompanied by activation in the frontoparietal working memory network, the resolution manipulation resulted in temporal and occipital activation. Furthermore, we found evidence of cross-modal reorganization in the secondary auditory cortex: DES had stronger activation and stronger connectivity between this and several other regions. We conclude that load and stimulus resolution have different neural underpinnings in the visual–verbal domain, which has consequences for current working memory models, and that for DES the secondary auditory cortex is involved in the binding of representations when task demands are low.
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期刊：
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