Multi-ancestry genome-wide analysis identifies shared genetic effects and common genetic variants for self-reported sleep duration.
Multi-ancestry genome-wide analysis identifies shared genetic effects and common genetic variants for self-reported sleep duration.
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多祖先全基因组分析确定了自我报告的睡眠持续时间的共同遗传效应和常见遗传变异。
DOI：
10.1093/hmg/ddad101
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发表时间：
2023
影响因子：
3.5
通讯作者：
Saxena,R
中科院分区：
文献类型：
--
作者：
Scammell,BH;Tchio,C;Song,Y;Nishiyama,T;Louie,TL;Dashti,HS;Nakatochi,M;Zee,PC;Daghlas,I;Momozawa,Y;Cai,J;Ollila,HM;Redline,S;Wakai,K;Sofer,T;Suzuki,S;Lane,JM;Saxena,R
睡眠时间短(≤每晚6小时)和睡眠时间长(≥每晚9小时)都与患慢性病的风险增加有关。尽管有证据表明习惯性睡眠时间与疾病风险有关，但人们对普通人群中睡眠时间的遗传决定因素知之甚少，特别是在欧洲(EUR)人群之外。在这里，我们报告了78个欧洲血统睡眠持续时间单核苷酸多态(SNPs)的多基因得分与非洲人(n= 7288；P=0.003)、东亚人(n=13 618；P=6×10−4)和南亚人(n= 7485；P=0.025)的睡眠时间相关，但在西班牙裔/拉丁裔队列中没有关联(n= 8726；P=0.71)。此外，在关于习惯性睡眠持续时间的全基因组关联研究的泛祖先(N= 483 235)荟萃分析中，73个基因座与全基因组的统计学意义相关。对5个基因座(HACD2、COG5、PRR12、SH3RF1和KCNQ5)的追踪发现PRR12和COG5在脑组织中的表达-数量性状基因座，以及与心血管和神经精神特征的多效性关联。总体而言，我们的结果表明，睡眠时间的遗传基础至少在不同的祖先群体中是部分相同的。
Both short (≤6 h per night) and long sleep duration (≥9 h per night) are associated with increased risk of chronic diseases. Despite evidence linking habitual sleep duration and risk of disease, the genetic determinants of sleep duration in the general population are poorly understood, especially outside of European (EUR) populations. Here, we report that a polygenic score of 78 European ancestry sleep duration single-nucleotide polymorphisms (SNPs) is associated with sleep duration in an African (n= 7288;P =0.003), an East Asian (n =13 618;P =6 × 10−4) and a South Asian (n= 7485;P =0.025) genetic ancestry cohort, but not in a Hispanic/Latino cohort (n= 8726;P =0.71). Furthermore, in a pan-ancestry (N= 483 235) meta-analysis of genome-wide association studies (GWAS) for habitual sleep duration, 73 loci are associated with genome-wide statistical significance. Follow-up of five loci (nearHACD2,COG5,PRR12,SH3RF1andKCNQ5) identified expression-quantitative trait loci forPRR12andCOG5in brain tissues and pleiotropic associations with cardiovascular and neuropsychiatric traits. Overall, our results suggest that the genetic basis of sleep duration is at least partially shared across diverse ancestry groups.
流感以及呼吸道感染中病毒和细菌的相互作用。
影响因子：
1.6
作者：
C. G. Loosli
通讯作者：
C. G. Loosli
影响因子：
5.9
作者：
BAINE, WB;LUBY, JP;MARTIN, SM
通讯作者：
MARTIN, SM