Thermoresponsive Hydrogel-Enabled Thermostatic Photothermal Therapy for Enhanced Healing of Bacteria-Infected Wounds.
Thermoresponsive Hydrogel-Enabled Thermostatic Photothermal Therapy for Enhanced Healing of Bacteria-Infected Wounds.
复制标题
启用热凝胶水凝胶的恒温光热疗法，可增强细菌感染的伤口的愈合。
DOI：
10.1002/advs.202206865
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发表时间：
2023-04
期刊：
影响因子：
15.1
通讯作者：
Zhu, Chunlei
中科院分区：
文献类型：
--
作者：
Fu, Hao;Xue, Ke;Zhang, Yongxin;Xiao, Minghui;Wu, Kaiyu;Shi, Linqi;Zhu, Chunlei
关键词：
光热疗法（PTT）已成为治疗细菌感染的一种有吸引力的技术。然而，在常规PTT中，不受控制的热量产生不可避免地会对健康组织和/或器官造成热损伤。因此，开发一种智能和通用的策略将光热平衡温度调节到预设的安全阈值是至关重要的。本文报道了一种热反应性水凝胶恒温PTT系统，用于增强细菌感染伤口的愈合。在该体系中，由光热纳米材料产生的近红外（NIR）触发的热自发地转移到具有较低临界溶液温度（LCST）的热响应水凝胶中，通过形成相当大的光散射中心来阻止近红外穿透，导致其快速相变。这种动态可逆的过程自动调节光热平衡温度到LCST型水凝胶的相变点。与温度不受控制的常规PTT相比，具有严重热损伤的热响应性水凝胶恒温PTT可以有效地保护健康组织和/或器官，通过有效的细菌清除显着加速伤口愈合。本研究建立了一个智能、简单、通用的PTT平台，在安全、有效地治疗细菌性皮肤感染方面具有很大的前景。据报道，一种热反应性水凝胶激活的恒温光热治疗系统可促进细菌感染伤口的愈合。利用水凝胶的可逆相变特性，系统光热平衡温度可以自动调节到水凝胶的相变点，用于智能光热治疗，对健康组织和/或器官的热损伤可以忽略不计。
Photothermal therapy (PTT) has emerged as an attractive technique for the treatment of bacterial infections. However, the uncontrolled heat generation in conventional PTT inevitably causes thermal damages to healthy tissues and/or organs. It is thus essential to develop a smart and universal strategy to regulate the photothermal equilibrium temperature to a preset safe threshold. Herein, a thermoresponsive hydrogel‐enabled thermostatic PTT system for enhanced healing of bacteria‐infected wounds is reported. In this system, the near‐infrared (NIR)‐triggered heat generation by photothermal nanomaterials is spontaneously transferred to a thermoresponsive hydrogel with a lower critical solution temperature (LCST), leading to its rapid phase transition by forming considerable light‐scattering centers to block NIR penetration. Such a dynamic and reversible process automatically regulates the photothermal equilibrium temperature to the phase‐transition point of the LCST‐type hydrogel. In contrast to temperature‐uncontrolled conventional PTT with severe thermal damages, the thermoresponsive hydrogel‐enabled thermostatic PTT provides effective protection on healthy tissues and/or organs, which remarkably accelerates wound healing by efficient bacterial eradication. This study establishes a smart, simple and universal PTT platform, holding great promise in the safe and efficient treatment of bacterial skin infections. A thermoresponsive hydrogel‐enabled thermostatic photothermal therapy system is reported for enhanced healing of bacteria‐infected wounds. Taking advantage of the reversible phase transition properties of the hydrogel, the system photothermal equilibrium temperature can be automatically regulated to the phase‐transition point of the hydrogel, which is employed for smart photothermal therapy with negligible thermal damages to healthy tissues and/or organs.
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