Associations of electrocardiographic P-wave characteristics with left atrial function, and diffuse left ventricular fibrosis defined by cardiac magnetic resonance: The PRIMERI Study.
Associations of electrocardiographic P-wave characteristics with left atrial function, and diffuse left ventricular fibrosis defined by cardiac magnetic resonance: The PRIMERI Study.
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DOI：
10.1016/j.hrthm.2014.09.044
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发表时间：
2015-01
期刊：
影响因子：
5.5
通讯作者：
Tereshchenko, Larisa G.
中科院分区：
文献类型：
--
作者：
Win, Theingi Tiffany;Venkatesh, Bharath Ambale;Volpe, Gustavo J.;Mewton, Nathan;Rizzi, Patricia;Sharma, Ravi K.;Strauss, David G.;Lima, Joao A.;Tereshchenko, Larisa G.
V1的P-末端力量异常(PTFV1)与心力衰竭、中风、房颤(AF)和死亡的风险增加有关。我们的目标是探索左心室(LV)弥漫性纤维化与左房(LA)功能和左房电活动的心电测量之间的关系。91例无房颤患者(平均年龄59.5岁，男性61.5%，高加索人65.9%)合并器质性心脏病(心电图宽空间QRS-T角≥105°±Selvester QRS积分≥5)，但有35%的患者接受了临床、心脏磁共振和静息心电图检查。采用2腔和4腔长轴位图像进行多模式组织追踪，获得左房功能指数。使用T1标测和晚期Gd增强来评估弥漫性左室纤维化和瘢痕的存在。用12SL TM算法自动测量V1波幅(PPaV1)、时限(PPdV1)、平均P时限、PR间期和P轴的P质数。PTFV1为PPaV1与PPdV1的乘积。在调整人口学、体重指数、左房最大容量指数、有无瘢痕和左心室重量指数后的线性回归分析中，左心室间质纤维化每增加十次，与PPTFV1阴性异常增加0.76 mV*ms[(95%CI−1.42to−0.09)，P=0.025]、PPdV1延长15.3ms[(95%CI 6.9to23.8)，P=0.001]、平均P波间期延长5.4ms[(95%CI0.9to10.0)，P=0.020]相关。左心室纤维化不影响左房功能。PPaV1和PTFV1与左房容量增加、左房射血分数和左房功能下降相关。LV间质纤维化与PTFV1异常、PPdV1延长、P波时限延长有关，但不影响LA功能。
Abnormal P-terminal force in V1 (PTFV1) is associated with an increased risk of heart failure, stroke, atrial fibrillation (AF) and death. Our goal was to explore associations of left ventricular (LV) diffuse fibrosis with left atrium (LA) function and ECG measures of LA electrical activity. AF-free patients (n=91, mean age 59.5, 61.5% men, 65.9% Caucasian) with structural heart disease (wide spatial QRS-T angle≥105° ± Selvester QRS score≥5 on ECG) but LV ejection fraction >35% underwent clinical evaluation, cardiac magnetic resonance and resting ECG. LA function indices were obtained by multimodality tissue tracking using 2 and 4-chamber long-axis images. T1 mapping and late gadolinium enhancement were used to assess diffuse LV fibrosis and presence of scar. P-prime in V1 amplitude (PPaV1) and duration (PPdV1), averaged P-duration, PR interval and P-axis were automatically measured using 12SL TM algorithm. PTFV1 was calculated as product of PPaV1 by PPdV1. In linear regression after adjustment for demographic, body mass index, LA volumemax index, presence of scar and LV mass index, each decile increase in LV interstitial fibrosis was associated with 0.76mV*ms increase in negative abnormal PTFV1 [(95%CI −1.42 to −0.09), P=0.025], 15.3ms prolongation in PPdV1 [(95%CI 6.9 to 23.8), P=0.001], and 5.4ms widening in averaged P-duration [(95%CI 0.9 to 10.0), P=0.020]. LV fibrosis did not affect LA function. PPaV1 and PTFV1 were associated with an increase in LA volumes, decrease in LAEF and LA reservoir function. LV interstitial fibrosis is associated with abnormal PTFV1, prolonged PPdV1 and P-duration, but does not affect LA function.
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DOI：
10.1111/anec.12084
发表时间：
2014-03
期刊：
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
影响因子：
--
作者：
Murthy S;Rizzi P;Mewton N;Strauss DG;Liu CY;Volpe GJ;Marchlinski FE;Spooner P;Berger RD;Kellman P;Lima JA;Tereshchenko LG
通讯作者：
Tereshchenko LG
影响因子：
24
作者：
Neilan, Tomas G.;Shah, Ravi V.;Abbasi, Siddique A.;Farhad, Hoshang;Groarke, John D.;Dodson, John A.;Coelho-Filho, Otavio;McMullan, Ciaran J.;Heydari, Bobak;Michaud, Gregory F.;John, Roy M.;van der Geest, Rob;Steigner, Michael L.;Blankstein, Ron;Jerosch-Herold, Michael;Kwong, Raymond Y.
通讯作者：
Kwong, Raymond Y.
影响因子：
2.8
作者：
Gotsman, Israel;Keren, Andre;Zwas, Donna R.
通讯作者：
Zwas, Donna R.
影响因子：
3.2
作者：
MCLENACHAN, JM;DARGIE, HJ
通讯作者：
DARGIE, HJ
影响因子：
24
作者：
Mewton, Nathan;Liu, Chia Ying;Croisille, Pierre;Bluemke, David;Lima, Joao A. C.
通讯作者：
Lima, Joao A. C.