A contemporary review of snoRNAs in cardiovascular health: RNA modification and beyond.
A contemporary review of snoRNAs in cardiovascular health: RNA modification and beyond.
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DOI：
10.1016/j.omtn.2023.102087
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发表时间：
2024-03-12
期刊：
影响因子：
--
通讯作者：
Garikipati, Venkata Naga Srikanth
中科院分区：
文献类型：
--
作者：
Jagielski, Noah Peter;Rai, Amit Kumar;Rajan, K. Shanmugha;Mangal, Vatsal;Garikipati, Venkata Naga Srikanth
随着心血管疾病继续成为全球死亡的主要原因，正在进行开创性的研究以减轻其影响。这篇综述研究了小核仁RNA（SNORNA）的潜力，并有机会将这些分子剂用作心脏特异性心血管问题的治疗生物标志物。通过研究SNORNA生物发生，功能和在心血管疾病中的作用，本综述将我们对SNORNAS的过去和现在知识与当前的科学文献联系起来。考虑到SNORNAS的最初发现以及此后分析snornas在疾病中的作用的研究，我们期待着揭示许多其他非规范功能，这些功能可能会导致研究人员更接近寻找心血管疾病的预防和治愈方法。
SNORNA是对各种RNA类型（包括rRNA，mRNA，tRNA和snRNA）的非编码RNA进行表演的RNA。该手稿探讨了在细胞和分子水平上对心血管疾病（CVD）的潜在促进者探索的snornas，并将其作为CVD的潜在诊断标记和治疗剂。
As cardiovascular diseases continue to be the leading cause of death worldwide, groundbreaking research is being conducted to mitigate their effects. This review looks into the potential of small nucleolar RNAs (snoRNAs) and the opportunity to use these molecular agents as therapeutic biomarkers for cardiovascular issues specific to the heart. Through an investigation of snoRNA biogenesis, functionality, and roles in cardiovascular diseases, this review relates our past and present knowledge of snoRNAs to the current scientific literature. Considering the initial discovery of snoRNAs and the studies thereafter analyzing the roles of snoRNAs in disease, we look forward to uncovering many other noncanonical functions that could lead researchers closer to finding preventive and curative solutions for cardiovascular diseases. snoRNAs are noncoding RNAs performing epitranscriptomic modifications on various RNA types, including rRNA, mRNA, tRNA, and snRNA. This manuscript explores snoRNAs as potential contributors to cardiovascular diseases (CVDs) at cellular and molecular levels, presenting them as potential diagnostic markers and therapeutics for CVDs.
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