Glial differentiation predicts poor clinical outcome in primitive neuroectodermal brain tumors.
Glial differentiation predicts poor clinical outcome in primitive neuroectodermal brain tumors.
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神经胶质分化预示着原始神经外胚层脑肿瘤的不良临床结果。
DOI：
10.1002/ana.410390410
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Phillips,PC
中科院分区：
文献类型：
--
作者：
Janss,AJ;Yachnis,AT;Silber,JH;Trojanowski,JQ;Lee,VM;Sutton,LN;Perilongo,G;Rorke,LB;Phillips,PC
中枢神经系统的原始神经外胚层肿瘤（PNET），包括髓母细胞瘤（PNET/MB），是儿童最常见的恶性脑肿瘤。这些肿瘤通常表达神经胶质分化（胶质细胞酸性蛋白，GFAP）、神经元分化（神经丝蛋白，NFP）和/或光感受器分化（视网膜抗原）的特征性蛋白。为了确定预后意义的生物学因素，在86例PNNI患者的肿瘤标本中，通过微波抗原增强后的免疫组化评价了胶质细胞、神经元或感光细胞抗原的表达。然后将分化模式与患者无复发生存期进行比较。PNET免疫组化和临床变量的多变量分析表明，GFAP表达的肿瘤复发风险是不表达GFAP或NFP的肿瘤的6.7倍。复发风险的增加与GFAP表达量直接相关。与不表达GFAP的肿瘤相比，表现出GFAP染色细胞团块或薄片的肿瘤与复发风险增加3.0倍相关，无论其他分化的免疫组织化学证据如何，而分散的GFAP染色与复发风险增加无关。这些发现表明，GFAP在PNIPs中的表达具有与目前用于预测临床结果的最重要的临床因素相当的预后能力。
Primitive neuroectodermal tumors (PNETs) of the central nervous system, including medulloblastomas (PNET/MB), are the most common malignant brain tumor of childhood. These tumors often express proteins characteristic of glial differentiation (glial fibrillary acidic protein, GFAP), neuronal differentiation (neurofilament proteins, NFPs), and/or photoreceptor differentiation (retinals antigen). To identify biological factors of prognostic significance in PNETs, the expression of glial, neuronal, or photoreceptor antigens was evaluated in the tumor specimens of 86 patients with PNETs by immunohistochemistry after microwave antigen enhancement. Patterns of differentiation were then compared with patient relapse‐free survival. Multivariate analysis of PNET immunohistochemistry and clinical variables indicated GFAP expression conferred a 6.7‐fold greater risk of relapse than tumors that did not express GFAP or NFPs. Increased risk of relapse was directly related to the amount of GFAP expression. Tumors exhibiting clumps or sheets of GFAP‐staining cells were associated with a 3.0‐fold increased risk of relapse compared with tumors that did not express GFAP, irrespective of immunohistochemical evidence of other differentiation, while scattered GFAP staining was not associated with increased risk of relapse. These findings indicate that expression of GFAP in PNETs has prognostic power comparable with the most significant clinical factors currently used to predict clinical outcome.
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影响因子：
64.8
作者：
Capper D;Jones DTW;Sill M;Hovestadt V;Schrimpf D;Sturm D;Koelsche C;Sahm F;Chavez L;Reuss DE;Kratz A;Wefers AK;Huang K;Pajtler KW;Schweizer L;Stichel D;Olar A;Engel NW;Lindenberg K;Harter PN;Braczynski AK;Plate KH;Dohmen H;Garvalov BK;Coras R;Hölsken A;Hewer E;Bewerunge-Hudler M;Schick M;Fischer R;Beschorner R;Schittenhelm J;Staszewski O;Wani K;Varlet P;Pages M;Temming P;Lohmann D;Selt F;Witt H;Milde T;Witt O;Aronica E;Giangaspero F;Rushing E;Scheurlen W;Geisenberger C;Rodriguez FJ;Becker A;Preusser M;Haberler C;Bjerkvig R;Cryan J;Farrell M;Deckert M;Hench J;Frank S;Serrano J;Kannan K;Tsirigos A;Brück W;Hofer S;Brehmer S;Seiz-Rosenhagen M;Hänggi D;Hans V;Rozsnoki S;Hansford JR;Kohlhof P;Kristensen BW;Lechner M;Lopes B;Mawrin C;Ketter R;Kulozik A;Khatib Z;Heppner F;Koch A;Jouvet A;Keohane C;Mühleisen H;Mueller W;Pohl U;Prinz M;Benner A;Zapatka M;Gottardo NG;Driever PH;Kramm CM;Müller HL;Rutkowski S;von Hoff K;Frühwald MC;Gnekow A;Fleischhack G;Tippelt S;Calaminus G;Monoranu CM;Perry A;Jones C;Jacques TS;Radlwimmer B;Gessi M;Pietsch T;Schramm J;Schackert G;Westphal M;Reifenberger G;Wesseling P;Weller M;Collins VP;Blümcke I;Bendszus M;Debus J;Huang A;Jabado N;Northcott PA;Paulus W;Gajjar A;Robinson GW;Taylor MD;Jaunmuktane Z;Ryzhova M;Platten M;Unterberg A;Wick W;Karajannis MA;Mittelbronn M;Acker T;Hartmann C;Aldape K;Schüller U;Buslei R;Lichter P;Kool M;Herold-Mende C;Ellison DW;Hasselblatt M;Snuderl M;Brandner S;Korshunov A;von Deimling A;Pfister SM
通讯作者：
Pfister SM
影响因子：
9.7
作者：
Kahlert, Ulf D.;Maciaczyk, Donata;Maciaczyk, Jaroslaw
通讯作者：
Maciaczyk, Jaroslaw
影响因子：
11.1
作者：
Siebzehnrubl, Florian A.;Silver, Daniel J.;Tugertimur, Bugra;Deleyrolle, Loic P.;Siebzehnrubl, Dorit;Sarkisian, Matthew R.;Devers, Kelly G.;Yachnis, Antony T.;Kupper, Marius D.;Neal, Daniel;Nabilsi, Nancy H.;Kladde, Michael P.;Suslov, Oleg;Brabletz, Simone;Brabletz, Thomas;Reynolds, Brent A.;Steindler, Dennis A.
通讯作者：
Steindler, Dennis A.
影响因子：
4.7
作者：
Doyen J;Parks SK;Marcié S;Pouysségur J;Chiche J
通讯作者：
Chiche J
影响因子：
9.3
作者：
Ghosh D;Funk CC;Caballero J;Shah N;Rouleau K;Earls JC;Soroceanu L;Foltz G;Cobbs CS;Price ND;Hood L
通讯作者：
Hood L