How Broad Is Enough: The Host Range of Bacteriophages and Its Impact on the Agri-Food Sector.
How Broad Is Enough: The Host Range of Bacteriophages and Its Impact on the Agri-Food Sector.
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多宽泛才算足够：噬菌体的宿主范围及其对农业食品领域的影响
DOI：
10.1089/phage.2020.0036
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发表时间：
2021-06-01
期刊：
影响因子：
--
通讯作者：
Delaquis, Pascal
中科院分区：
文献类型：
--
作者：
Fong, Karen;Wong, Catherine W. Y.;Wang, Siyun;Delaquis, Pascal
具有广泛宿主范围的新型噬菌体（novel bacteriophage，简称novel）被一致地和常规地报道，但目前对“广泛宿主范围”的定义没有共识。随着越来越多的人使用微生物来开发人类病原体的检测和生物控制方法，解决与宿主范围相关的限制是很重要的。例如，未预料到的宿主范围宽度可能导致检测到非致病性靶标，从而增加假阳性率。此外，广泛的宿主范围通常在生物防治应用中是有利的，尽管对非目标物种有不期望的辅助作用的风险。在这里，我们讨论的研究进展，应用和广泛的主机范围内的细菌感染的关注在农业食品部门的人类病原体的尾广泛的主机范围内的重点影响。
Novel bacteriophages (phages) possessing a broad host range are consistently and routinely reported, yet there is presently no consensus on the definition of “broad host range.” As phages are increasingly being used in the development of methods for the detection and biocontrol of human pathogens, it is important to address the limitations associated with the host range. For instance, unanticipated host range breadth may result in the detection of nonpathogenic targets, thereby increasing the false-positive rate. Moreover, a broad host range is generally favored in biocontrol applications despite the risk of undesirable ancillary effects against nontarget species. Here, we discuss the research progress, applications, and implications of broad host range phages with a focus on tailed broad host range phages infecting human pathogens of concern in the Agri-Food sector.
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影响因子：
5.2
作者：
Fong K;LaBossiere B;Switt AIM;Delaquis P;Goodridge L;Levesque RC;Danyluk MD;Wang S
通讯作者：
Wang S
影响因子：
4.5
作者：
Costa, Pedro;Pereira, Carla;Almeida, Adelaide
通讯作者：
Almeida, Adelaide
影响因子：
5.2
作者：
Bryan D;El-Shibiny A;Hobbs Z;Porter J;Kutter EM
通讯作者：
Kutter EM
影响因子：
5.3
作者：
Bai, Jaewoo;Jeon, Byeonghwa;Ryu, Sangryeol
通讯作者：
Ryu, Sangryeol
影响因子：
6.7
作者：
Balasubramanian, Sowmya;Osburne, Marcia S.;Leong, John M.
通讯作者：
Leong, John M.