Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices
Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices
复制标题
抗惊厥药对海马切片中缺乏化学突触传递时发生的自发性癫痫样活动的影响
DOI：
10.1016/0006-8993(85)90338-5
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发表时间：
1985
期刊：
影响因子：
2.9
通讯作者：
Y. Yaari
中科院分区：
文献类型：
--
作者：
Udo Heinemann;S. Franceschetti;B. Hamon;Arthur Konnerth;Y. Yaari
Spontaneous epileptiform activity (SEA) develops in area CA1 of hippocampal slices, when the Ca2+concentration in the perfusate is lowered to 0.2 mM, at which level evoked chemical synaptic transmission is blocked. We investigated the effects of different anticonvulsants on this autonomous activity, in order to determine whether the antiepileptic effect can be ascribed to an influence on neuronal excitability. Carbamazepine was the most effective to block SEA at concentrations of 1–15 μM. Phenobarbital and phenytoin depressed SEA at concentrations of 25 μM. Valproate was effective at concentrations of 2–5 mM. Midazolam, a water-soluble benzodiazepine agonist and the N-methyl-d-aspartate antagonists,d-α-aminoadipic acid and 2-amino-7-phosphonoheptanoic acid were ineffective in blocking SEA suggesting that they exert their antiepileptic action by interference with synaptic mechanisms.
影响因子：
56.9
作者：
TAYLOR, CP;DUDEK, FE
通讯作者：
DUDEK, FE