Macrophages in tumor microenvironments and the progression of tumors.
Macrophages in tumor microenvironments and the progression of tumors.
复制标题
DOI：
10.1155/2012/948098
复制
发表时间：
2012
影响因子：
--
通讯作者：
Yang SM
中科院分区：
文献类型：
--
作者：
Hao NB;Lü MH;Fan YH;Cao YL;Zhang ZR;Yang SM
巨噬细胞是广泛分布的先天性免疫细胞，在对病原体的先天性和适应性免疫应答以及组织内稳态中发挥不可或缺的作用。巨噬细胞可被多种刺激激活，并极化为功能不同的表型。已经提出了两种不同的巨噬细胞亚群，包括经典活化（M1）和交替活化（M2）巨噬细胞。M1巨噬细胞表达一系列促炎细胞因子、趋化因子和效应分子，如IL-12、IL-23、TNF-α、iNOS和MHCI/II。相比之下，M2巨噬细胞表达多种抗炎分子，如IL-10、TGF-β和β-内酰胺酶1。在大多数肿瘤中，浸润的巨噬细胞被认为是M2表型，其为肿瘤生长提供免疫抑制微环境。此外，肿瘤相关巨噬细胞分泌许多细胞因子、趋化因子和蛋白酶，其促进肿瘤血管生成、生长、转移和免疫抑制。最近，还发现肿瘤相关巨噬细胞与癌症干细胞相互作用。这种相互作用导致肿瘤发生、转移和耐药性。因此，介导巨噬细胞抗肿瘤被认为是一种很有潜力的治疗手段。
Macrophages are widely distributed innate immune cells that play indispensable roles in the innate and adaptive immune response to pathogens and in-tissue homeostasis. Macrophages can be activated by a variety of stimuli and polarized to functionally different phenotypes. Two distinct subsets of macrophages have been proposed, including classically activated (M1) and alternatively activated (M2) macrophages. M1 macrophages express a series of proinflammatory cytokines, chemokines, and effector molecules, such as IL-12, IL-23, TNF-α, iNOS and MHCI/II. In contrast, M2 macrophages express a wide array of anti-inflammatory molecules, such as IL-10, TGF-β, and arginase1. In most tumors, the infiltrated macrophages are considered to be of the M2 phenotype, which provides an immunosuppressive microenvironment for tumor growth. Furthermore, tumor-associated macrophages secrete many cytokines, chemokines, and proteases, which promote tumor angiogenesis, growth, metastasis, and immunosuppression. Recently, it was also found that tumor-associated macrophages interact with cancer stem cells. This interaction leads to tumorigenesis, metastasis, and drug resistance. So mediating macrophage to resist tumors is considered to be potential therapy.
登录
查看更多内容
DOI：
10.1158/1078-0432.ccr-08-1283
发表时间：
2009-02-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Beck AH;Espinosa I;Edris B;Li R;Montgomery K;Zhu S;Varma S;Marinelli RJ;van de Rijn M;West RB
通讯作者：
West RB
影响因子：
20.3
作者：
Biswas, SK;Gangi, L;Sica, A
通讯作者：
Sica, A
影响因子：
11.2
作者：
Coffelt SB;Scandurro AB
通讯作者：
Scandurro AB
PD-L1 的过度表达与人类肝细胞癌的肿瘤侵袭性和术后复发显着相关。
影响因子：
11.5
作者：
Gao, Qiang;Wang, Xiao-Ying;Fan, Jia
通讯作者：
Fan, Jia
影响因子：
11.2
作者：
Dineen, Sean P.;Lynn, Kristi D.;Brekken, Rolf A.
通讯作者：
Brekken, Rolf A.