Lactic acid bacterial surface display of scytovirin inhibitors for anti-ebolavirus infection.
Lactic acid bacterial surface display of scytovirin inhibitors for anti-ebolavirus infection.
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DOI：
10.3389/fmicb.2023.1269869
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
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作者：
Scytovirin (SVN) is a lectin from cyanobacteria which has a strong inhibitory activity against Ebola virus infection. We engineered scytovirin as the inhibitor for surface display of lactic acid bacteria to block Ebola virus infection. Two different bacterial strains (Lactobacillus casei and Lactococcus lactis) were successfully engineered for scytovirin expression on the bacterial surface. These bacteria were found to be effective at neutralizing pseudotyped Ebolavirus in a cell-based assay. This approach can be utilized for prophylactic prevention, as well as for treatment. Since lactic acid bacteria can colonize the human body, a long-term efficacy could be achieved. Furthermore, this approach is also simple and cost-effective and can be easily applied in the regions of Ebola outbreaks in the developing countries.
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影响因子：
6.2
作者：
Vamvaka E;Evans A;Ramessar K;Krumpe LR;Shattock RJ;O'Keefe BR;Christou P;Capell T
通讯作者：
Capell T
DOI：
10.1016/j.bpobgyn.2012.01.010
发表时间：
2012-08
影响因子：
5.5
作者：
Karim, Salim S. Abdool;Baxter, Cheryl
通讯作者：
Baxter, Cheryl
影响因子：
5.9
作者：
Koharudin LM;Gronenborn AM
通讯作者：
Gronenborn AM
影响因子：
5.4
作者：
Huskens D;Schols D
通讯作者：
Schols D
影响因子：
4.6
作者：
Girard L;Birse K;Holm JB;Gajer P;Humphrys MS;Garber D;Guenthner P;Noël-Romas L;Abou M;McCorrister S;Westmacott G;Wang L;Rohan LC;Matoba N;McNicholl J;Palmer KE;Ravel J;Burgener AD
通讯作者：
Burgener AD