Associations between changes in adipokines and exposure to fine and ultrafine particulate matter in ambient air in Beijing residents with and without pre-diabetes.
Associations between changes in adipokines and exposure to fine and ultrafine particulate matter in ambient air in Beijing residents with and without pre-diabetes.
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DOI：
10.1136/bmjdrc-2020-001215
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发表时间：
2020-12
影响因子：
4.1
通讯作者：
Zhu T
中科院分区：
文献类型：
--
作者：
Chen W;Han Y;Wang Y;Chen X;Qiu X;Li W;Yao Y;Zhu T
暴露于颗粒物（PM）是糖尿病的一个危险因素，但其潜在机制尚不清楚。脂肪因子在糖代谢中起重要作用。本研究探讨了短期暴露于环境PM和脂肪因子水平之间的关联，并评估了代谢紊乱是否会增加PM引起的健康影响的易感性。在中国北京的一项小组研究（SCOPE，空气污染暴露对健康和糖尿病前期个体的心脏代谢和呼吸影响的比较研究）中，60名糖尿病前期个体和60名健康对照者完成了2至7次临床访视。使用线性混合效应模型评估了临床访视前1-14天期间血清脂联素、瘦素和β-内酰胺酶水平与PM2.5移动平均（MA）质量浓度和超细颗粒物（UFP）和累积型颗粒物（AMP）数浓度之间的相关性，以及代谢紊乱对任何此类相关性的影响。短期暴露于环境UFP和AMP与临床访视前1-14天的脂肪因子水平呈负相关。例如，在1天MA UFP暴露（6.0×103/cm 3）中，IQR每增加一次，脂联素、瘦素和β-内酰胺酶水平分别发生-14.0%（95% CI-20.9%，-6.4%）、-6.6%（95% CI-12.4%，-0.4%）和-8.5%（95% CI-14.5%，-2.2%）的变化。脂肪因子水平与PM2.5暴露之间没有显著相关性。在高胰岛素抵抗水平的参与者中，UFP和AMP暴露与脂联素水平的较大下降和瘦素水平的较弱变化相关。葡萄糖状态并没有改变PM诱导的脂肪因子水平的变化。高水平的胰岛素抵抗可加重UFP和AMP暴露对代谢的不利影响。
Exposure to particulate matter (PM) is a risk factor to diabetes, but the underlying mechanism is unclear. Adipokines play important roles in glucose metabolism. This study examined the associations between short-term exposure to ambient PM and adipokine levels and evaluated whether metabolic disorders could enhance susceptibility to PM-induced health effects. In a panel study (SCOPE, Study Comparing the Cardiometabolic and Respiratory Effects of Air Pollution Exposure on Healthy and Pre-diabetic Individuals) in Beijing, China, 60 pre-diabetic individuals and 60 healthy controls completed two to seven clinical visits. The associations between serum adiponectin, leptin, and resistin levels and the moving average (MA) mass concentration of PM2.5 and number concentrations of ultrafine particles (UFP) and accumulation-mode particles (AMP) during the 1–14 days prior to clinical visits, and the effects of metabolic disorders on any such associations, were evaluated using a linear mixed-effects model. Short-term exposure to ambient UFP and AMP was inversely associated with adipokine levels at 1–14 days prior to clinical visits. For example, each IQR increment in 1 day MA UFP exposure (6.0×103/cm3) was associated with −14.0% (95% CI −20.9%, −6.4%), −6.6% (95% CI −12.4%, −0.4%), and −8.5% (95% CI −14.5%, −2.2%) changes in adiponectin, leptin, and resistin levels, respectively. There was no significant association between adipokine levels and PM2.5 exposure. UFP and AMP exposure was associated with a greater decrease in adiponectin level and a weaker change in leptin level among participants with high insulin resistance levels. Glucose status did not modify PM-induced changes in adipokine levels. High level of insulin resistance could aggravate the adverse metabolic impact of exposure to UFP and AMP.
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影响因子：
37.8
作者：
O'Neill, MS;Veves, A;Schwartz, J
通讯作者：
Schwartz, J
影响因子：
5.6
作者：
Achari AE;Jain SK
通讯作者：
Jain SK
DOI：
10.1161/hypertensionaha.115.06237
发表时间：
2016-01
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Brook RD;Sun Z;Brook JR;Zhao X;Ruan Y;Yan J;Mukherjee B;Rao X;Duan F;Sun L;Liang R;Lian H;Zhang S;Fang Q;Gu D;Sun Q;Fan Z;Rajagopalan S
通讯作者：
Rajagopalan S
影响因子：
6
作者：
Han, Yiqun;Wang, Yanwen;Zhu, Tong
通讯作者：
Zhu, Tong
DOI：
10.1016/s0140-6736(12)60283-9
发表时间：
2012-06-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Tabák AG;Herder C;Rathmann W;Brunner EJ;Kivimäki M
通讯作者：
Kivimäki M