CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults.
CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults.
复制标题
血液和脂肪组织的CD147水平与肥胖糖尿病成年人的血管功能障碍相关。
DOI：
10.3390/jcdd9010007
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发表时间：
2021-12-28
影响因子：
2.4
通讯作者：
Mahmoud AM
中科院分区：
文献类型：
--
作者：
Ali MM;Mirza I;Naquiallah D;Hassan C;Masrur M;Bianco FM;Mahmoud AM
CD 147是一种糖蛋白，刺激基质金属蛋白酶（MMP）的产生，已知的心血管风险的贡献者。CD 147蛋白的活性依赖于其糖基化。然而，目前尚不清楚是否CD 147蛋白表达或糖基化的糖尿病环境的特点是高血糖症和丰富的糖基化终产物（AGEs）的影响。我们研究了循环和内脏脂肪组织（VAT）的CD 147水平及其与肥胖，肥胖糖尿病和非肥胖对照（n = 40，每个）的血管功能的相关性。与对照组相比，肥胖，特别是肥胖糖尿病受试者中VAT中的CD 147和糖基化CD 147蛋白的循环水平显著更高。肥胖糖尿病患者的肱动脉和小动脉血管反应性最低，颈动脉脉搏波速度（PWV，动脉硬度的测量）最高。CD 147与体重指数（BMI）、总脂肪量和内脏脂肪量、PWV、血糖、胰岛素、MMPs和AGEs的血浆水平呈正相关，与肱动脉和VAT-小动脉血管反应性和一氧化氮产生呈负相关。多元回归分析显示，BMI、体脂量、胰岛素和葡萄糖水平显著预测CD 147。我们的数据表明，肥胖受试者，特别是糖尿病受试者中较高水平的CD 147与血管功能障碍和几种心脏代谢风险因素有关。
CD147 is a glycoprotein that stimulates the production of matrix metalloproteinases (MMPs), known contributors to cardiovascular risk. The activity of CD147 protein depends on its glycosylation. However, it is unclear whether CD147 protein expression or glycosylation are influenced by the diabetic milieu characterized by hyperglycemia and abundant glycation-end-products (AGEs). We examined the circulating and visceral adipose tissue (VAT) levels of CD147 and their correlation with vascular function in obese, obese diabetic, and non-obese controls (n = 40, each). The circulating levels of CD147 and the glycosylated CD147 protein in VAT were considerably higher in obese, particularly obese diabetic subjects compared to controls. Obese diabetics had the lowest brachial and arteriolar vasoreactivity and the highest carotid pulse-wave velocity (PWV, a measure of arterial stiffness) among the three groups. CD147 correlated positively with body mass index (BMI), total and visceral fat mass, PWV, and plasma levels of glucose, insulin, MMPs, and AGEs and negatively with brachial artery and VAT-arteriolar vasoreactivity and nitric oxide production. Multivariate regression revealed that BMI, body fat mass, insulin, and glucose levels significantly predicted CD147. Our data suggest that higher levels of CD147 in obese subjects, particularly those with diabetes, are linked to vascular dysfunction and several cardiometabolic risk factors.
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影响因子：
4
作者：
Grass GD;Toole BP
通讯作者：
Toole BP
影响因子：
5.9
作者：
Mahmoud, Abeer M.;Hwang, Chueh-Lung;Phillips, Shane A.
通讯作者：
Phillips, Shane A.
影响因子：
3.3
作者：
Chiu, Ping-Fang;Su, Shih-Li;Liu, Chin-San
通讯作者：
Liu, Chin-San
影响因子：
6
作者：
Mahmoud AM;Ali MM
通讯作者：
Ali MM
DOI：
10.11817/j.issn.1672-7347.2020.200018
发表时间：
2020-08-28
期刊：
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
影响因子：
--
作者：
Guo, Jia;Zhang, Jianglin;Qi, Min
通讯作者：
Qi, Min