Pathobiology of cancer metastasis: a short account.
Pathobiology of cancer metastasis: a short account.
复制标题
DOI：
10.1186/1475-2867-12-24
复制
发表时间：
2012-06-07
影响因子：
5.8
通讯作者：
Lemmer J
中科院分区：
文献类型：
--
作者：
Feller L;Kramer B;Lemmer J
癌症起始细胞表现出正常干细胞的异常功能和表型特征，它们是通过多种细胞遗传学和/或表观遗传学改变的积累而进化而来的。正常干细胞功能所必需的信号转导通路在癌细胞中异常表达，癌细胞表型在癌变和转移中起重要作用。局部肿瘤的进展、转移和转移性肿瘤的生长是由癌细胞与各种基质细胞（包括成纤维细胞、巨噬细胞、骨髓源性干细胞和祖细胞）之间的直接细胞间和旁分泌相互作用介导的。这些相互作用介导基底膜屏障的破坏和血管生成，既发生在原发肿瘤的侵袭前，也发生在远处转移部位；将原发肿瘤细胞吸引到候选转移部位；并促进原发肿瘤细胞和远处转移细胞的增殖、存活和生长。本文的目的是强调正常干细胞的一些遗传程序与参与转移过程的癌细胞之间的相似性。
Cancer-initiating cells display aberrant functional and phenotypic characteristics of normal stem cells from which they evolved by accumulation of multiple cytogenetic and/or epigenetic alterations. Signal transduction pathways which are essential for normal stem cell function are abnormally expressed by cancer cells, with a cancer cell phenotype playing an essential role in cancerization and metastasis. Local tumour progression, metastasis and metastatic tumour growth are mediated by direct cell-to-cell and paracrine reciprocal interactions between cancer cells and various stromal cells including fibroblasts, macrophages, bone marrow derived stem cells and progenitor cells. These interactions mediate breakdown of basement membrane barriers and angiogenesis both locally at the invasive front of the primary tumour and at the distant metastatic site; attract primary tumour cells to the candidate metastatic site; and promote proliferation, survival and growth of primary tumour cells and of metastatic cells at their distant site. It is the purpose of this article to highlight the analogies between some of the genetic programs of normal stem cells, and of cancer cells participating in the process of metastasis.
登录
查看更多内容
影响因子：
3.7
作者：
Roato, Ilaria;D'Amelio, Patrizia;Ferracini, Riccardo
通讯作者：
Ferracini, Riccardo
DOI：
10.3816/cgc.2005.n.008
发表时间：
2005-06-01
期刊：
Clinical prostate cancer
影响因子：
--
作者：
Pienta, Kenneth J;Loberg, Robert
通讯作者：
Loberg, Robert
影响因子：
15.9
作者：
Minn, AJ;Kang, YB;Massagué, J
通讯作者：
Massagué, J
影响因子：
50.3
作者：
Kang, YB;Siegel, PM;Massagué, J
通讯作者：
Massagué, J
影响因子：
8
作者：
Li, Z. G.;Yang, J.;Navone, N. M.
通讯作者：
Navone, N. M.