Cortico-cortical projections in mouse visual cortex are functionally target specific.
Cortico-cortical projections in mouse visual cortex are functionally target specific.
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DOI：
10.1038/nn.3300
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发表时间：
2013-02
影响因子：
25
通讯作者：
Reid, R. Clay
中科院分区：
文献类型：
--
作者：
Glickfeld, Lindsey L.;Andermann, Mark L.;Bonin, Vincent;Reid, R. Clay
初级感觉皮层中的神经元具有不同的反应特性，而高级皮层区域是专门化的。特定的连接可能是重要的区域专业化，特别是在小鼠，其中相邻的神经元功能多样。为了研究更高的视觉区域是否从初级视觉皮层（V1）接收功能特异性输入，我们使用双光子钙成像来测量V1的轴突在三个具有不同空间和时间频率偏好的区域中分叉的反应。我们发现，在每个区域的突触前扣的视觉偏好是不同的，并匹配受体神经元的平均偏好。这种特异性不能解释的V1内的组织，而是由于更大的密度和更大的响应幅度的功能匹配的终扣。来自单层（第5层）和次级视觉皮层的投射也与其目标区域相匹配。因此，特定信息向下游目标的传输可能是皮质-皮质通信的一般特征。
Neurons in primary sensory cortex have diverse response properties, whereas higher cortical areas are specialized. Specific connectivity may be important for areal specialization, particularly in the mouse, where neighboring neurons are functionally diverse. To examine whether higher visual areas receive functionally specific input from primary visual cortex (V1), we used two-photon calcium imaging to measure responses of axons from V1 arborizing in three areas with distinct spatial and temporal frequency preferences. We found that visual preferences of presynaptic boutons in each area were distinct and matched the average preferences of recipient neurons. This specificity could not be explained by organization within V1 and instead was due to both a greater density and greater response amplitude of functionally matched boutons. Projections from a single layer (layer 5) and from secondary visual cortex were also matched to their target areas. Thus, transmission of specific information to downstream targets may be a general feature of cortico-cortical communication.
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影响因子：
64.8
作者：
Bock, Davi D.;Lee, Wei-Chung Allen;Kerlin, Aaron M.;Andermann, Mark L.;Hood, Greg;Wetzel, Arthur W.;Yurgenson, Sergey;Soucy, Edward R.;Kim, Hyon Suk;Reid, R. Clay
通讯作者：
Reid, R. Clay
影响因子：
25
作者：
Hofer SB;Ko H;Pichler B;Vogelstein J;Ros H;Zeng H;Lein E;Lesica NA;Mrsic-Flogel TD
通讯作者：
Mrsic-Flogel TD
影响因子：
5.3
作者：
Morishima, M;Kawaguchi, Y
通讯作者：
Kawaguchi, Y
影响因子：
25
作者：
Allen, CB;Celikel, T;Feldman, DE
通讯作者：
Feldman, DE
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.