Differential connectivity and response dynamics of excitatory and inhibitory neurons in visual cortex.
Differential connectivity and response dynamics of excitatory and inhibitory neurons in visual cortex.
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DOI：
10.1038/nn.2876
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发表时间：
2011-07-17
影响因子：
25
通讯作者：
Mrsic-Flogel TD
中科院分区：
文献类型：
--
作者：
Hofer SB;Ko H;Pichler B;Vogelstein J;Ros H;Zeng H;Lein E;Lesica NA;Mrsic-Flogel TD
感觉处理过程中的神经元反应受到皮质内连接的组织和感觉刺激的统计特征的影响。这些内在和外在因素如何支配兴奋性和抑制性群体的活动尚不清楚。利用体内双光子钙成像和体外细胞内记录，我们研究了小鼠视皮层锥体细胞（PC）和表达小白蛋白的快速尖峰（PV/FS）中间神经元的突触连接性，特征选择性和网络活动之间的依赖关系。在PC人群中，神经元相关性的模式在很大程度上是刺激依赖性的，这表明他们的反应并不强烈占主导地位的功能偏向经常性连接。相比之下，视觉刺激只有弱修改的PV/FS细胞的共激活模式，这些广泛调谐的interneurons收到非常密集和强大的突触输入附近的PC与不同的功能选择性的观察一致。因此，前馈和循环网络的影响决定了兴奋性和抑制性合奏活动在根本上不同的方式。
Neuronal responses during sensory processing are influenced both by the organization of intracortical connections and the statistical features of sensory stimuli. How these intrinsic and extrinsic factors govern activity of excitatory and inhibitory populations is unclear. Using two-photon calcium imaging in vivo and intracellular recordings in vitro, we investigated the dependencies between synaptic connectivity, feature selectivity and network activity in pyramidal cells (PCs) and parvalbumin-expressing fast-spiking (PV/FS) interneurons in mouse visual cortex. In PC populations, patterns of neuronal correlations were largely stimulus-dependent, indicating that their responses were not strongly dominated by functionally biased recurrent connectivity. In contrast, visual stimulation only weakly modified co-activation patterns of PV/FS cells, consistent with the observation that these broadly tuned interneurons received very dense and strong synaptic input from nearby PCs with diverse feature selectivities. Therefore feedforward and recurrent network influences determine the activity of excitatory and inhibitory ensembles in fundamentally different ways.
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