Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study.

Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study.
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兴奋剂依赖性的异质性:国家药物滥用治疗临床试验网络研究。

DOI:
10.1080/10550490902787031
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发表时间:
2009-05
期刊:
The American journal on addictions
影响因子:
--
通讯作者:
Brooner RK
Brooner RK
中科院分区:
其他
文献类型:
--
作者:
Wu LT;Blazer DG;Patkar AA;Stitzer ML;Wakim PG;Brooner RK

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我们调查了参与临床试验网络(CTN)多点研究的门诊兴奋剂使用者对可卡因和安非他明依赖的DSM-IV亚型的存在(有或没有身体依赖)。确定了三个相互排斥的群体:主要可卡因使用者(n=287)、主要苯丙胺使用者(n=99)和双重使用者(可卡因和苯丙胺;n=29)。采用潜伏型和Logistic回归分析方法对不同亚型进行分析。吸食可卡因的人与吸食安非他明的人在年龄和种族/族裔方面不同。有四种不同的主要可卡因使用者:非依赖(15%)、强迫使用(14%)、耐受和强迫使用(15%)和生理依赖(耐受、戒断和强迫使用;56%)。主要苯丙胺使用者分为三类:非依赖(11%)、中度生理依赖(31%)和生理依赖(58%)。无论使用何种兴奋剂,大多数女性吸毒者都属于最严重或生理依赖的人群。这些结果支持新出现的DSM-V中的亚型依赖。
We investigated the presence of DSM-IV subtyping for dependence on cocaine and amphetamines (with versus without physical dependence) among outpatient stimulant users enrolled in a multisite study of the Clinical Trials Network (CTN). Three mutually exclusive groups were identified: primary cocaine users (n = 287), primary amphetamine users (n = 99), and dual users (cocaine and amphetamines; n = 29). Distinct subtypes were examined with latent class and logistic regression procedures. Cocaine users were distinct from amphetamine users in age and race/ethnicity. There were four distinct classes of primary cocaine users: non-dependence (15%), compulsive use (14%), tolerance and compulsive use (15%), and physiological dependence (tolerance, withdrawal, and compulsive use; 56%). Three distinct classes of primary amphetamine users were identified: non-dependence (11%), intermediate physiological dependence (31%), and physiological dependence (58%). Regardless of stimulants used, most female users were in the most severe or the physiological dependence group. These results lend support for subtyping dependence in the emerging DSM-V.
DOI: 10.1097/00004583-199808000-00015
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