Significant SNPs have limited prediction ability for thyroid cancer.
Significant SNPs have limited prediction ability for thyroid cancer.
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显着的 SNP 对甲状腺癌的预测能力有限
DOI：
10.1002/cam4.211
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发表时间：
2014-06
期刊：
影响因子：
4
通讯作者：
Wang, Jiucun
中科院分区：
文献类型：
--
作者：
Guo, Shicheng;Wang, Yu-Long;Li, Yi;Jin, Li;Xiong, Momiao;Ji, Qing-Hai;Wang, Jiucun
最近，两项独立的 GWAS 和大量病例对照研究在不同人群中进行，发现并验证了五种与甲状腺癌显着相关的遗传变异（rs965513、rs944289、rs116909374、rs966423 和 rs2439302）。我们对中国汉族人群中的上述五个单核苷酸多态性（SNP）进行了基因分型，并利用九种机器学习方法进行了甲状腺癌风险预测。我们发现4个SNP与中国汉族人群的甲状腺癌显着相关，而rs116909374没有观察到多态性。较小的家族相对风险（1.02-1.05）和预测甲状腺癌的能力有限（AUC：0.54-0.60）表明临床潜力有限。四个重要的 SNP 对甲状腺癌的预测能力有限。
Recently, five thyroid cancer significantly associated genetic variants (rs965513, rs944289, rs116909374, rs966423, and rs2439302) have been discovered and validated in two independent GWAS and numerous case–control studies, which were conducted in different populations. We genotyped the above five single nucleotide polymorphisms (SNPs) in Han Chinese populations and performed thyroid cancer-risk predictions with nine machine learning methods. We found that four SNPs were significantly associated with thyroid cancer in Han Chinese population, while no polymorphism was observed for rs116909374. Small familial relative risks (1.02–1.05) and limited power to predict thyroid cancer (AUCs: 0.54–0.60) indicate limited clinical potential. Four significant SNPs have limited prediction ability for thyroid cancer.
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