Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population.
Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population.
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DOI：
10.1371/journal.pone.0166077
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Nakaji S
中科院分区：
文献类型：
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作者：
Kamba A;Daimon M;Murakami H;Otaka H;Matsuki K;Sato E;Tanabe J;Takayasu S;Matsuhashi Y;Yanagimachi M;Terui K;Kageyama K;Tokuda I;Takahashi I;Nakaji S
糖皮质激素(GC)是众所周知的诱导胰岛素抵抗的药物。然而，在人体生理条件下，GCs对胰岛素分泌的影响还没有得到很好的描述。在此，我们在生理条件下精确评估了GCs对胰岛素分泌/细胞功能的影响。一项基于人群的研究纳入了2014年Iwaki研究中登记的1071名日本人(390名男性，681名女性；年龄54.1±15.1岁)，这些人排除了服用糖尿病药物或类固醇治疗的个人，被纳入本研究。用稳态模型评估空腹血糖和胰岛素水平(分别为HOMA-R和HOMA-BUB)，研究血清皮质醇水平与胰岛素抵抗/分泌的相关性。单变量线性回归分析显示，血清皮质醇水平与HOMA-B相关(？=-0.134，p<；0.001)，但与HOMA-R无关(？=0.042，p=0.172)。对年龄、性别和与HOMA指数相关的多种临床特征进行调整后，结果相似(HOMA-？0.062，p=0.025；？经HOMA-R校正后，血清皮质醇水平与HOMA-B之间的相关性仍然显著(？=-0.057，p=0.034)。当根据血清皮质醇水平对受试者进行分类时，在调整了包括HOMA-R在内的多个因素(优势比1.26，95%可信区间1.03-1.54)后，最高的三分位数比最低的三分位数的胰岛素分泌减少的风险更大(定义为低于三分之一的霍马伯(≤)70)。总而言之，在日本人群中，较高的血清皮质醇水平与生理皮质醇范围内胰岛素分泌减少显著相关。
Glucocorticoids (GCs) are well known to induce insulin resistance. However, the effect of GCs on insulin secretion has not been well characterized under physiological conditions in human. We here evaluated the effect of GCs on insulin secretion/ß-cell function precisely in a physiological condition. A population-based study of 1,071 Japanese individuals enrolled in the 2014 Iwaki study (390 men, 681 women; aged 54.1 ± 15.1 years), those excluded individuals taking medication for diabetes or steroid treatment, were enrolled in the present study. Association between serum cortisol levels and insulin resistance/secretion assessed by homeostasis model assessment using fasting blood glucose and insulin levels (HOMA-R and HOMA-ß, respectively) were examined. Univariate linear regression analyses showed correlation of serum cortisol levels with HOMA-ß (ß = -0.134, p <0.001) but not with HOMA-R (ß = 0.042, p = 0.172). Adjustments for age, gender, and the multiple clinical characteristics correlated with HOMA indices showed similar results (HOMA-ß: ß = -0.062, p = 0.025; HOMA-R: ß = -0.023, p = 0.394). The correlation between serum cortisol levels and HOMA-ß remained significant after adjustment for HOMA- R (ß = -0.057, p = 0.034). When subjects were tertiled based on serum cortisol levels, the highest tertile was at greater risk of decreased insulin secretion (defined as lower one third of HOMA-ß (≤70)) than the lowest tertile, after adjustment for multiple factors including HOMA- R (odds ratio 1.26, 95% confidence interval 1.03–1.54). In conclusion, higher serum cortisol levels are significantly associated with decreased insulin secretion in the physiological cortisol range in a Japanese population.
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影响因子：
3.7
作者：
Blondeau B;Sahly I;Massouridès E;Singh-Estivalet A;Valtat B;Dorchene D;Jaisser F;Bréant B;Tronche F
通讯作者：
Tronche F
影响因子：
9.8
作者：
LONGANO, CA;FLETCHER, HP
通讯作者：
FLETCHER, HP
影响因子：
5.1
作者：
Matsuhisa, Munehide;Yamasaki, Yoshimitsu;Matsuzawa, Yuji
通讯作者：
Matsuzawa, Yuji
影响因子：
3.8
作者：
Shimon, Ilan
通讯作者：
Shimon, Ilan
影响因子：
--
作者：
BEARD, JC;HALTER, JB;PORTE, D
通讯作者：
PORTE, D