Are Thyroid Functions Affected in Multisystem Inflammatory Syndrome in Children?
Are Thyroid Functions Affected in Multisystem Inflammatory Syndrome in Children?
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DOI：
10.4274/jcrpe.galenos.2022.2022-4-7
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发表时间：
2022-12-01
影响因子：
1.9
通讯作者：
Yılmaz D
中科院分区：
文献类型：
--
作者：
Elvan-Tüz A;Ayrancı İ;Ekemen-Keleş Y;Karakoyun İ;Çatlı G;Kara-Aksay A;Karadağ-Öncel E;Dündar BN;Yılmaz D
与2019年冠状病毒病相关的儿童多系统炎症综合征(MIS-C)的定义是，在最近或当前患有严重急性呼吸道综合征-冠状病毒-2感染或暴露的儿童中，存在有记录的发热、炎症和至少两个多系统参与的迹象，并且缺乏替代微生物诊断。在这项研究中，我们评估了患有MIS-C的儿童患者的甲状腺功能测试，以了解下丘脑-垂体-甲状腺轴是如何受到影响的，并检查疾病严重程度与甲状腺功能之间的关系。这项病例对照研究在2021年1月至2021年9月期间进行。病例组36例，对照组72例。记录患者的人口学特征、临床表现、炎症标志物、甲状腺功能测试和甲状腺抗体水平。对健康对照组进行甲状腺功能检查。与健康对照组比较，MI-C组游离三碘甲腺原氨酸(FT_3)水平降低，而健康组游离甲状腺激素(FT_4)水平降低(P<0.001，P=0.001)。尽管对照组的FT4水平显著低于对照组，但与年龄合适的参考间隔相比没有发现显著差异(p=0.318)。当MISC病例按重症监护需求分层时，住进重症监护病房的患者和接受类固醇治疗的患者的FT3水平也较低(p=0.043，p<；0.001)。由于内分泌系统关键地协调和调节重要的代谢和生化途径，因此研究MIS-C的内分泌功能可能是有益的。这些结果表明，低水平的ft3水平与MIS-C的诊断和重症监护需求之间存在关联。需要进一步的研究来预测预后和制定长期的随访管理计划。
Multisystem inflammatory syndrome in children (MIS-C), associated with Coronavirus disease-2019, is defined as the presence of documented fever, inflammation, and at least two signs of multisystem involvement and lack of an alternative microbial diagnosis in children who have recent or current Severe acute respiratory syndrome-Coronavirus-2 infection or exposure. In this study, we evaluated thyroid function tests in pediatric cases with MIS-C in order to understand how the hypothalamus-pituitary-thyroid axis was affected and to examine the relationship between disease severity and thyroid function. This case-control study was conducted between January 2021 and September 2021. The patient group consisted of 36 MIS-C cases, the control group included 72 healthy children. Demographic features, clinical findings, inflammatory markers, thyroid function tests, and thyroid antibody levels in cases of MIS-C were recorded. Thyroid function tests were recorded in the healthy control group. When MIS-C and healthy control groups were compared, free triiodothyronine (fT3) level was lower in MIS-C cases, while free thyroxine (fT4) level was found to be lower in the healthy group (p<0.001, p=0.001, respectively). Although the fT4 level was significantly lower in controls, no significant difference was found compared with the age-appropriate reference intervals (p=0.318). When MIS-C cases were stratified by intensive care requirement, fT3 levels were also lower in those admitted to intensive care and also in those who received steroid treatment (p=0.043, p<0.001, respectively). Since the endocrine system critically coordinates and regulates important metabolic and biochemical pathways, investigation of endocrine function in MIS-C may be beneficial. These results show an association between low fT3 levels and both diagnosis of MIS-C and requirement for intensive care. Further studies are needed to predict the prognosis and develop a long-term follow-up management plan.
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DOI：
10.4103/ijciis.ijciis_29_17
发表时间：
2018-07
影响因子：
--
作者：
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影响因子：
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