A fatal yellow fever virus infection in China: description and lessons.
A fatal yellow fever virus infection in China: description and lessons.
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DOI：
10.1038/emi.2016.89
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发表时间：
2016-07-13
影响因子：
13.2
通讯作者：
Li, Dexin
中科院分区：
文献类型：
--
作者：
Chen, Zhihai;Liu, Lin;Lv, Yanning;Zhang, Wei;Li, Jiandong;Zhang, Yi;Di, Tian;Zhang, Shuo;Liu, Jingyuan;Li, Jie;Qu, Jing;Hua, Wenhao;Li, Chuan;Wang, Peng;Zhang, Quanfu;Xu, Yanli;Jiang, Rongmeng;Wang, Qin;Chen, Lijuan;Wang, Shiwen;Pang, Xinghuo;Liang, Mifang;Ma, Xuejun;Li, Xingwang;Wang, Quanyi;Zhang, Fujie;Li, Dexin
黄热病（YF）是非洲和南美洲热带地区流行的一种病毒性疾病。自2016年初以来，安哥拉爆发黄热病疫情。2016年3月，一名从安哥拉回国的32岁中国男子入院治疗，确诊为我国首例输入性黄热病病例。每天对患者进行临床观察、血液病毒RNA检测、血清学检测和治疗。在Vero细胞中分离病毒，并使用下一代基因组测序平台对完整病毒基因组进行测序和分析。患者发病后第3天出现出血热、黄疸和少尿，并迅速进展为多系统器官衰竭，肝酶、胰酶和心肌酶极度升高。尽管进行了强化支持治疗，患者还是死亡。肝活检显示严重的多小叶坏死。在整个疾病的临床过程中均可检测到病毒 RNA。全基因组序列分析显示，该病毒属于Angola71基因型。尽管该病毒已在安哥拉传播了45年，但与1971年收集的病毒相比，膜和包膜蛋白中仅观察到14个氨基酸替换，且未观察到氨基酸变化。中国输入性黄热病病例的存在表明，随着国家间商务旅行的增加，非洲黄热病疫情可导致该病的国际传播。因此，黄热病疫苗的生产和使用是一个紧迫的问题。
Yellow fever (YF) is a viral disease endemic to the tropical regions of Africa and South America. An outbreak of YF has been occurring in Angola, since the beginning of 2016. In March 2016, a 32-year-old Chinese man who returned from Angola was hospitalized and diagnosed with the first case of imported YF in China. Clinical observations, blood viral RNA detection, serological testing and treatments for the patient were performed daily. The virus was isolated in Vero cells, and the complete viral genome was sequenced and analyzed using the next-generation genomic sequencing platform. The patient presented with hemorrhagic fever, jaundice and oliguria at day 3 after onset, which rapidly progressed to multisystem organ failure with extremely elevated liver, pancreatic and myocardial enzymes. The patient died despite the intensive supportive treatments that were performed. A liver biopsy showed severe and multilobular necrosis. Viral RNA was detectable throughout the clinical course of the disease. Whole-genomic sequence analysis revealed that the virus belongs to the Angola71 genotype. Although the virus has been circulating in Angola for 45 years, only 14 amino-acid substitutions and no amino-acid changes were observed in the membrane and envelope proteins compared with the virus collected in 1971. The presence of this imported YF case in China indicated that with the increase in business travel among countries, YF outbreaks in Africa can lead to the international spread of the disease. The production and use of YF vaccines is, therefore, an urgent issue.
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影响因子：
30.3
作者：
Pierson TC;Fremont DH;Kuhn RJ;Diamond MS
通讯作者：
Diamond MS
DOI：
10.1016/j.trstmh.2006.02.019
发表时间：
2007-02-01
影响因子：
2.2
作者：
Quaresma, Juarez A. S.;Barros, Vera L. R. S.;Duarte, Maria I. S.
通讯作者：
Duarte, Maria I. S.
DOI：
10.1016/s1473-3099(01)00016-0
发表时间：
2001-08-01
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Monath, T P
通讯作者：
Monath, T P
影响因子：
1.7
作者：
Gardner CL;Ryman KD
通讯作者：
Ryman KD
影响因子：
3.7
作者：
Pang Z;Li A;Li J;Qu J;He C;Zhang S;Li C;Zhang Q;Liang M;Li D
通讯作者：
Li D