Detection of metabolites in rabbit brain by 13C NMR spectroscopy following administration of [1‐13C]glucose
Detection of metabolites in rabbit brain by 13C NMR spectroscopy following administration of [1‐13C]glucose
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给予[1-13C]葡萄糖后通过 13C NMR 光谱检测兔脑中的代谢物
DOI：
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发表时间：
1986
影响因子：
3.3
通讯作者：
R. Shulman
中科院分区：
文献类型：
--
作者：
K. Behar;O. Petroff;J. Prichard;J. Alger;R. Shulman
静脉输注[1 - 13 C]葡萄糖后，用表面线圈收集活兔脑的1H-去偶13 C NMR光谱（20.2 MHz）。在输注15分钟内，检测到葡萄糖的α和β端基异构体，此后不久，检测到谷氨酸和（或）谷氨酰胺的C4、C3和C2位碳原子。在吸入氧气从30%减少到5%后，检测到乳酸C3。乳酸共振的强度在缺氧过程中逐渐上升，后来在恢复与氧气下降。通过1H NMR测量动脉血糖的13 C分数同位素富集，提供关于血糖标记的速率和程度的信息。出版社：Academic Press，Inc.
1H‐decoupled 13C NMR spectra (20.2 MHz) of the living rabbit brain were collected with a surface coil following the intravenous infusion of [1‐13C]glucose. Within 15 min of infusion, the α and β anomers of glucose were detected and, shortly thereafter, the carbon atoms at positions C4, C3, and C2 of glutamate and(or) glutamine. After reductions of inspired oxygen from 30 to 5%, lactate C3 was detected. The intensity of the lactate resonance rose progressively during hypoxia and later fell during recovery with oxygen. The 13C fractional isotopic enrichment of arterial blood glucose was measured by 1H NMR providing information on the rate and extent of blood glucose labeling. © 1986 Academic Press, Inc.
肝脏代谢的 13C 核磁共振和 14C 示踪剂研究的比较。
DOI：
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发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Cohen,SM;Rognstad,R;Shulman,RG;Katz,J
通讯作者：
Katz,J
DOI：
10.1073/pnas.80.6.1603
发表时间：
1983
影响因子：
11.1
作者：
Neurohr,KJ;Barrett,EJ;Shulman,RG
通讯作者：
Shulman,RG