Neural underpinnings of the evidence accumulator.

Neural underpinnings of the evidence accumulator.
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证据蓄能器的神经基础。

DOI:
10.1016/j.conb.2016.01.003
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发表时间:
2016-04
影响因子:
5.7
通讯作者:
Hanks TD
Hanks TD
中科院分区:
医学2区
文献类型:
--
作者:
Brody CD;Hanks TD

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逐渐积累的证据有利于一个或另一个选择被认为是许多不同类型的决策的核心组成部分,并已成为许多非人类灵长类动物神经生理学研究的主题。但它的神经回路机制仍然是个谜。调查它在啮齿动物最近已成为可能,促进扰动实验,以描绘相关的因果电路,以及其他工具的应用更容易在啮齿动物。此外,刺激设计和分析的进步有助于研究相关的神经编码。作为对正在进行的非人类灵长类动物研究的补充,这些新的模型系统和工具将该领域置于一个令人兴奋的时刻,这表明证据积累背后的动态电路机制可能很快就会被揭示出来。
Gradual accumulation of evidence favoring one or another choice is considered a core component of many different types of decisions, and has been the subject of many neurophysiological studies in non-human primates. But its neural circuit mechanisms remain mysterious. Investigating it in rodents has recently become possible, facilitating perturbation experiments to delineate the relevant causal circuit, as well as the application of other tools more readily available in rodents. In addition, advances in stimulus design and analysis have aided studying the relevant neural encoding. In complement to ongoing nonhuman primate studies, these newly available model systems and tools place the field at an exciting time that suggests that the dynamical circuit mechanisms underlying accumulation of evidence could soon be revealed.
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