Network Medicine for Alzheimer's Disease and Traditional Chinese Medicine.
Network Medicine for Alzheimer's Disease and Traditional Chinese Medicine.
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DOI:
10.3390/molecules23051143
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发表时间:
2018-05-11
期刊:
影响因子:
--
通讯作者:
Huang X
中科院分区:
文献类型:
--
作者:
Jarrell JT;Gao L;Cohen DS;Huang X
Alzheimer’s Disease (AD) is a neurodegenerative condition that currently has no known cure. The principles of the expanding field of network medicine (NM) have recently been applied to AD research. The main principle of NM proposes that diseases are much more complicated than one mutation in one gene, and incorporate different genes, connections between genes, and pathways that may include multiple diseases to create full scale disease networks. AD research findings as a result of the application of NM principles have suggested that functional network connectivity, myelination, myeloid cells, and genes and pathways may play an integral role in AD progression, and may be integral to the search for a cure. Different aspects of the AD pathology could be potential targets for drug therapy to slow down or stop the disease from advancing, but more research is needed to reach definitive conclusions. Additionally, the holistic approaches of network pharmacology in traditional Chinese medicine (TCM) research may be viable options for the AD treatment, and may lead to an effective cure for AD in the future.
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影响因子:
4.3
作者:
Guo H;Liu L;Chen J;Xu Y;Jie X
通讯作者:
Jie X
影响因子:
4.6
作者:
Ahnaou A;Moechars D;Raeymaekers L;Biermans R;Manyakov NV;Bottelbergs A;Wintmolders C;Van Kolen K;Van De Casteele T;Kemp JA;Drinkenburg WH
通讯作者:
Drinkenburg WH
影响因子:
4.8
作者:
Cheng XR;Cui XL;Zheng Y;Zhang GR;Li P;Huang H;Zhao YY;Bo XC;Wang SQ;Zhou WX;Zhang YX
通讯作者:
Zhang YX
影响因子:
--
作者:
Huang HJ;Lee CC;Chen CY
通讯作者:
Chen CY
DOI:
10.19540/j.cnki.cjcmm.20170905.008
发表时间:
2017-11-01
期刊:
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
影响因子:
--
作者:
Huang, Li-Ping;Yan, Bo;Zhou, Mao-Fu
通讯作者:
Zhou, Mao-Fu