Network Medicine for Alzheimer's Disease and Traditional Chinese Medicine.

Network Medicine for Alzheimer's Disease and Traditional Chinese Medicine.
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DOI:
10.3390/molecules23051143
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发表时间:
2018-05-11
期刊:
Molecules (Basel, Switzerland)
影响因子:
--
通讯作者:
Huang X
Huang X
中科院分区:
其他
文献类型:
--
作者:
Jarrell JT;Gao L;Cohen DS;Huang X

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阿尔茨海默病(AD)是一种神经退行性疾病,目前尚无已知的治愈方法。网络医学 (NM) 领域不断扩展的原理最近已应用于 AD 研究。 NM 的主要原理提出,疾病比一个基因的一种突变要复杂得多,它整合了不同的基因、基因之间的联系以及可能包括多种疾病的途径,以创建全面的疾病网络。应用 NM 原理得出的 AD 研究结果表明,功能性网络连接、髓鞘形成、髓样细胞以及基因和通路可能在 AD 进展中发挥着不可或缺的作用,并且可能是寻找治愈方法不可或缺的一部分。 AD 病理学的不同方面可能是药物治疗的潜在目标,以减缓或阻止疾病的进展,但需要更多的研究才能得出明确的结论。此外,中医研究中网络药理学的整体方法可能是AD治疗的可行选择,并可能在未来带来AD的有效治愈。
Alzheimer’s Disease (AD) is a neurodegenerative condition that currently has no known cure. The principles of the expanding field of network medicine (NM) have recently been applied to AD research. The main principle of NM proposes that diseases are much more complicated than one mutation in one gene, and incorporate different genes, connections between genes, and pathways that may include multiple diseases to create full scale disease networks. AD research findings as a result of the application of NM principles have suggested that functional network connectivity, myelination, myeloid cells, and genes and pathways may play an integral role in AD progression, and may be integral to the search for a cure. Different aspects of the AD pathology could be potential targets for drug therapy to slow down or stop the disease from advancing, but more research is needed to reach definitive conclusions. Additionally, the holistic approaches of network pharmacology in traditional Chinese medicine (TCM) research may be viable options for the AD treatment, and may lead to an effective cure for AD in the future.
在 fMRI 数据集上使用高阶功能网络的最小生成树进行阿尔茨海默病分类
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